Association of systemic inflammation and body mass index with survival in patients with resectable gastric or gastroesophageal junction adenocarcinomas  

作　　者：Xianchun Gao Yanan Pan Weili Han Caie Hu Chenchen Wang Ling Chen Yong Guo Yupeng Shi Yan Pan Huahong Xie Liping Yao Jianjun Yang Jianyong Zheng Xiaohua Li Xiaonan Liu Liu Hong Jipeng Li Mengbin Li Gang Ji Zengshan Li Jielai Xia Qingchuan Zhao Daiming Fan Kaichun Wu Yongzhan Nie 

机构地区：[1]State Key Laboratory of Cancer Biology and National Clinical Research Center for Digestive Diseases,Xijing Hospital,Air Force Medical University of PLA,Xi’an 710032,China [2]School of Life Science,Northwest University,Xi’an 710069,China [3]Department of Gastroenterology,The First Affiliated Hospital of Xi’an Medical University,Xi'an 710021,China [4]State Key Laboratory of Cancer Biology,Department of Pathology,Xijing Hospital and School of Basic Medicine,Air Force Medical University of PLA,Xi'an 710032,China [5]Department of Medical Statistics,School of Preventive Medicine,Air Force Medical University of PLA,Xi'an 710032,China

出　　处：《Cancer Biology & Medicine》2021年第1期283-297,共15页癌症生物学与医学（英文版）

基　　金：supported by the National Major Research and the Innovation Program of China(Grant No.2016YFC1303200);the National Key R&D Program of China(Grant No.2017YFC0908300);the National Natural Science Foundation of China(Grant No.81972761)。

摘　　要：Objective:The systemic inflammation index and body mass index(BMI)are easily accessible markers that can predict mortality.However,the prognostic value of the combined use of these two markers remains unclear.The goal of this study was therefore to evaluate the association of these markers with outcomes based on a large cohort of patients with gastric cancer.Methods:A total of 2,542 consecutive patients undergoing radical surgery for gastric or gastroesophageal junction adenocarcinoma between 2009 and 2014 were included.Systemic inflammation was quantified by the preoperative neutrophil-to-lymphocyte ratio(NLR).High systemic inflammation was defined as NLR≥3,and underweight was defined as BMI<18.5 kg/m2.Results:Among 2,542 patients,NLR≥3 and underweight were common[627(25%)and 349(14%),respectively].In the entire cohort,NLR≥3 or underweight independently predicted overall survival(OS)[hazard ratio(HR):1.236,95%confidence interval(95%CI):1.069–1.430;and HR:1.600,95%CI:1.350–1.897,respectively]and recurrence-free survival(RFS)(HR:1.230,95%CI:1.054–1.434;and HR:1.658,95%CI:1.389–1.979,respectively).Patients with both NLR≥3 and underweight(vs.neither)had much worse OS(HR:2.445,95%CI:1.853–3.225)and RFS(HR:2.405,95%CI:1.802–3.209).Furthermore,we observed similar results in subgroup analyses according to pathological stage,age,and postoperative chemotherapy.Conclusions:Our results showed that preoperative elevated NLR and decreased BMI had a significant negative effect on survival.Underweight combined with severe inflammation could enhance prognostication.Taking active therapeutic measures to reduce inflammation and increase nutrition may help improve outcomes.

关 键 词：Gastric cancer neutrophil-to-lymphocyte ratio body mass index PROGNOSIS systemic inflammation index 

分 类 号：R735[医药卫生—肿瘤]