新型冠状病毒体外诊断技术研发现状与展望  

Research Progress of in Vitro Diagnostic Technologies for SARS-CoV-2

作　　者：范月蕾[1] 王跃[1] 王恒哲 李丹丹[1] 毛开云[1] FAN Yue-lei;WANG Yue;WANG Heng-zhe;LI Dan-dan;MAO Kai-yun(Shanghai Information Center for Life Sciences,Shanghai Instiute of Nutrition and Health,Chinese Academy of Sciences,Shanghai 200031,China)

机构地区：[1]中国科学院上海生命科学信息中心中国科学院上海营养与健康研究所,上海200031

出　　处：《中国生物工程杂志》2021年第2期150-161,共12页China Biotechnology

基　　金：上海市2020年度“科技创新行动计划”软科学重点项目(20692109200)资助项目。

摘　　要：随着新型冠状病毒(SARS-CoV-2)引发的全球疫情不断加剧,新型冠状病毒体外诊断技术与产品的研发成为全球生物医药领域关注的重点,体外诊断技术与产品的研发创新对于提升新发突发传染病的防控能力有着重要的意义。对2019年12月至2020年12月期间国内外新型冠状病毒体外诊断技术与产品的研发现状与发展趋势进行了综述,即包括聚合酶链反应技术、核酸等温扩增技术、免疫层析技术、化学发光免疫分析技术等传统分子诊断技术与免疫诊断技术,也包括CRISPR技术、生物传感器技术、纳米技术等新兴技术在新型冠状病毒检测中的应用,以期为新发突发传染病体外诊断技术的研发与政府的科技决策提供参考。With the intensification of coronavirus pandemic,the research and development of in vitro diagnostic technologies and products for SARS-CoV-2 attracts great attention in the global biomedical field.The research and development of in vitro diagnostic technologies and products is of great importance in enhancing the ability to prevent and control emerging infectious diseases.The global research status and future trend of SARSCoV-2 diagnostic technologies and products was reviewed,including not only the traditional molecular diagnostic and immunodiagnostic technologies,but also the application of new technologies,such as CRISPR technology,biosensor technology,nanotechnology,in SARS-CoV-2 testing,and the research and development strategy and technical characteristics were also analyzed in order to provide a reference for the development of in vitro diagnostic technologies for emerging infectious diseases and the science and technology decision making of the government.

关 键 词：新型冠状病毒 体外诊断 疫情防控 

分 类 号：Q819[生物学—生物工程]