Cell-type-specific memory consolidation driven by translational control  

作　　者：Qing Zhang Isabel Bestard-Lorigados Weihong Song 

机构地区：[1]Townsend Family Laboratories,Department of Psychiatry,The University of British Columbia,Vancouver,BC,Canada [2]Institute of Aging,School of Mental Health and Kangning Hospital,The Second Affiliated Hospital and Yuying Children’s Hospital,Wenzhou Medical University,Wenzhou,China

出　　处：《Signal Transduction and Targeted Therapy》2021年第2期206-208,共3页信号转导与靶向治疗（英文）

基　　金：Q.Z.is supported by the UBC Four Year Fellowship and DMCBH Innovation Fund Graduate Trainee Award;I.B.L.is supported by the UBC Four Year Fellowship.W.S.was the holder of Canada Research Chair in Alzheimer's disease.

摘　　要：Dr.Sonenberg’s group has significantly contributed to the understanding of translational control in learning and memory.In a recent Nature article,they further reported the cell-typespecific translational control underlying memory consolidation.1 Long-term potentiation(LTP)has been widely acknowledged as one of the main cellular models of learning and memory.Generally,there are two components of LTP driven by different stimulations and mechanisms.The early phase of LTP(E-LTP)and short-term memory(STM)are evoked for short periods and are temporary,relying primarily on modifications of pre-existing proteins.The late phase of LTP(L-LTP)and consequent longterm memory(LTM)are elicited by strong and repetitive stimulation and are long-lasting,requiring new protein synthesis.

关 键 词：synthesis. TRANSLATIONAL STIMULATION 

分 类 号：Q42[生物学—神经生物学]