Methionine metabolism in chronic liver diseases:an update on molecular mechanism and therapeutic implication  

作　　者：Zhanghao Li Feixia Wang Baoyu Liang Ying Su Sumin Sun Siwei Xia Jiangjuan Shao Zili Zhang Min Hong Feng Zhang Shizhong Zheng 

机构地区：[1]Department of Pharmacology,Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica,Nanjing University of Chinese Medicine,Nanjing 210023,China [2]Department of Pharmacology,Jiangsu Key Laboratory of Therapeutic Material of Chinese Medicine,Nanjing University of Chinese Medicine,Nanjing 210023,China [3]Department of Pharmacology,State Key Laboratory Cultivation Base for TCM Quality and Efficacy,Nanjing University of Chinese Medicine,Nanjing 210023,China

出　　处：《Signal Transduction and Targeted Therapy》2021年第1期17-25,共9页信号转导与靶向治疗（英文）

基　　金：This work was financially supported by the National Natural Science Foundation of China(81870423 and 82073914);the Major Project of the Natural Science Research of Jiangsu Higher Education Institutions(19KJA310005);the Open Project of Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica(JKLPSE202005,JKLPSE201815,and JKLPSE 201804);the Project of the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD);the Postgraduate Research&Practice Innovation Program of Jiangsu Province(SJCX20_0536 and KYCX20_1493).

摘　　要：As one of the bicyclic metabolic pathways of one-carbon metabolism,methionine metabolism is the pivot linking the folate cycle to the transsulfuration pathway.In addition to being a precursor for glutathione synthesis,and the principal methyl donor for nucleic acid,phospholipid,histone,biogenic amine,and protein methylation,methionine metabolites can participate in polyamine synthesis.Methionine metabolism disorder can aggravate the damage in the pathological state of a disease.In the occurrence and development of chronic liver diseases(CLDs),changes in various components involved in methionine metabolism can affect the pathological state through various mechanisms.A methionine-deficient diet is commonly used for building CLD models.The conversion of key enzymes of methionine metabolism methionine adenosyltransferase(MAT)1 A and MAT2A/MAT2B is closely related to fibrosis and hepatocellular carcinoma.In vivo and in vitro experiments have shown that by intervening related enzymes or downstream metabolites to interfere with methionine metabolism,the liver injuries could be reduced.Recently,methionine supplementation has gradually attracted the attention of many clinical researchers.Most researchers agree that adequate methionine supplementation can help reduce liver damage.Retrospective analysis of recently conducted relevant studies is of profound significance.This paper reviews the latest achievements related to methionine metabolism and CLD,from molecular mechanisms to clinical research,and provides some insights into the future direction of basic and clinical research.

关 键 词：synthesis. LINKING DONOR 

分 类 号：R575[医药卫生—消化系统]