Effects of a multimodal exercise protocol on functional outcomes,epigenetic modulation and brain-derived neurotrophic factor levels in institutionalized older adults:a quasi-experimental pilot study  

作　　者：Iasmin Fraga Camila Weber Wériton Baldo Galiano Lucio Iraci Mariana Wohlgemuth Gabriela Morales Camila Cercato Juliana Rodriguez Daniela Pochmann Caroline Dani Pérsia Menz Adriane Dal Bosco Viviane Rostirola Elsner 

机构地区：[1]Programa de Pós-Graduação em Ciências Biológicas:Fisiologia,Universidade Federal do Rio Grande do Sul,Porto Alegre,RS,Brasil [2]Curso de Fisioterapia do Centro Universitário Metodista-IPA,Porto Alegre,RS,Brasil [3]Programa de Pós-Graduação em Biociências e Reabilitação,Centro Universitário Metodista-IPA,Porto Alegre,RS,Brasil [4]Physiotherapist,working in Long-Term Institutions,Porto Alegre,RS,Brasil

出　　处：《Neural Regeneration Research》2021年第12期2479-2485,共7页中国神经再生研究（英文版）

摘　　要：Epigenetic changes have been shown to be associated with both aging process and aging-related diseases.There is evidence regarding the benefits of physical activity on the functionality,cognition,and quality of life of institutionalized older adults,however,the molecular mechanisms involved are not elucidated.The purpose of this pilot study was to investigate the effects of a multimodal exercise intervention on functional outcomes,cognitive performance,quality of life(QOL),epigenetic markers and brain-derived neurotrophic factor(BDNF)levels among institutionalized older adult individuals.Participants(n=8)without dementia who were aged 73.38±11.28 years and predominantly female(87.5%)were included in this quasi-experimental pilot study.A multimodal exercise protocol(cardiovascular capacity,strength,balance/agility andflexibility,perception and cognition)consisted of twice weekly sessions(60 minutes each)over 8 weeks.Balance(Berg Scale),mobility(Timed Up and Go test),functional capacity(Six-Minute Walk test),cognitive function(Mini-Mental State Examination)and QOL(the World Health Organization Quality of Life-BREF Scale questionnaire)were evaluated before and after the intervention.Blood sample(15 mL)was also collected before and after intervention for analysis of biomarkers global histone H3 acetylation and brain-derived neurotrophic factor levels.Significant improvements were observed in cognitive function,balance,mobility,functional capacity and QOL after the intervention.In addition,a tendency toward an increase in global histone H3 acetylation levels was observed,while brain-derived neurotrophic factor level remained unchanged.This study provided evidence that an 8-week multimodal exercise protocol has a significant effect on ameliorating functional outcomes and QOL in institutionalized older adult individuals.In addition,it was also able to promote cognitive improvement,which seems to be partially related to histone hyperacetylation status.The Ethics Research Committee of Centro Universitário Metodista-IPA

关 键 词：aging balance brain-derived neurotrophic factor cognition EPIGENETICS physical exercise quality of life risk of falling 

分 类 号：R493[医药卫生—康复医学] R364[医药卫生—临床医学]