富组氨酸糖蛋白在肿瘤中的作用研究进展  

Research Progress on the Functions of Histidine-rich Glycoprotein in Tumors

作　　者：张方圆[1] 刘连胜 李胜文[1] ZHANG Fang-yuan;LIU Lian-sheng;LI Sheng-wen(School of Clinical Medicine,Tsinghua University,Beijing 100084,China;Guangzhou Regenerative Medicine and Health Guangdong Laboratory,Guangzhou 510700,China)

机构地区：[1]清华大学临床医学院,北京100084 [2]广州再生医学与健康广东省实验室,广东广州510700

出　　处：《肿瘤学杂志》2021年第2期142-147,共6页Journal of Chinese Oncology

摘　　要：富组氨酸糖蛋白(HRG)是一种具有多结构域,能够与多种配体相互作用并在多种生物学过程中发挥重要作用的血浆糖蛋白。早期对HRG的研究主要集中在凝血、纤维蛋白溶解、细胞黏附和免疫复合物清除等功能。近年来,HRG在调控肿瘤血管生成、调节肿瘤免疫和预测肿瘤预后的研究逐渐增多,HRG在肿瘤发生发展中的重要性逐渐被发现。全文对HRG在肿瘤中的作用相关研究进展进行综述。Histidine-rich glycoprotein(HRG)is a kind of plasma glycoprotein with a multidomain structure,which interacts with many ligands and plays important role in many biological processes.Researches of HRG have mainly focused on its roles in coagulation,fibrinolysis,cell adhesion,and clearance of immune complex;however,researches on its functions in tumor angiogenesis,antitumor immunity,and prognosis prediction increased gradually.This article reviews the recent advances of researches on HRG in tumors.

关 键 词：富组氨酸糖蛋白 肿瘤 血管生成调节剂 肿瘤微环境 预后 

分 类 号：R73[医药卫生—肿瘤]