血液系统恶性肿瘤患者的生育力保存  

Fertility preservation in patients with hematological malignancies

作　　者：李净羽 梁琳琳 范英英 李蕾 张翠莲 Li Jingyu;Liang Linlin;Fan Yingying;Li Lei;Zhang Cuilian(Zhengzhou University People's Hospital,Henan Provincial People's Hospital,Henan Provincial Reproductive Hospital,Henan Joint International Research Laboratory of Reproductive Bioengineering,Zhengzhou 450003,China)

机构地区：[1]郑州大学人民医院,河南省人民医院,河南省生殖医院,河南省生殖医学工程国际联合实验室,450003

出　　处：《中华生殖与避孕杂志》2021年第2期167-172,共6页Chinese Journal of Reproduction and Contraception

摘　　要：随着肿瘤诊断和治疗方案的不断改进,癌症患者的生存率得到了显著提高。烷基化化疗和全身照射(total body irradiation,TBI)等性腺毒性抗癌方案经常用于治疗年轻的血液系统恶性肿瘤患者,这可能导致女性卵巢功能不全(premature ovarian insufficiency,POI)或男性生殖细胞大量丢失。本文在针对生育力保存的背景、方法和适应证的基础上,对血液系统恶性肿瘤患者在生育力保存方法中的选择及应用做一简要综述,以期为血液系统肿瘤患者生育力保存的临床处理提供相关知识。With the continuous improvement of cancer diagnosis and treatment methods,the survival rate of cancer patients has been significantly improved.Gonadotoxic anticancer regimens such as alkylating chemotherapy and total body irradiation(TBI)are often used to treat young patients with hematological malignancies,but may cause premature ovarian insufficiency(POI)in women or massive loss of germ cells in men.On the basis of the background,methods and indications of fertility preservation,this review briefly summarizes the selection and application of fertility preservation methods for patients with hematological malignancies in order to provide them clinical suggestions for fertility preservation.

关 键 词：生育力保存 血液系统恶性肿瘤 淋巴瘤 白血病 肿瘤生殖学 

分 类 号：R733[医药卫生—肿瘤]