神经胶质瘤中肿瘤相关巨噬细胞研究进展  

Progress of tumor-associated macrophages in glioma

作　　者：张裕 段虎斌[1] Zhang Yu;Duan Hubin(Department of Neurosurgery,First Hospital of Shanxi Medical University,Taiyuan 030001,China)

机构地区：[1]山西医科大学第一医院神经外科,太原030001

出　　处：《肿瘤研究与临床》2021年第2期153-156,共4页Cancer Research and Clinic

基　　金：国家自然科学基金青年基金(30600637);中国博士后科学基金特别资助项目(2019T120195);山西省归国留学人员重点资助项目(2016-4)。

摘　　要：肿瘤相关巨噬细胞(TAM)是异质性细胞群体,是肿瘤微环境中炎性细胞的主要成分。这些细胞在神经胶质瘤中部分源自中枢神经系统小胶质细胞和循环单核细胞,并与神经胶质瘤的血管生成、免疫抑制、肿瘤进展和侵袭有关。文章综述了TAM通过各种途径促进神经胶质瘤发展的潜在机制,为神经胶质瘤的靶向治疗提供了新的可能性。Tumor-associated macrophage(TAM)is a group of heterogeneous cells and a major component of inflammatory cells in the tumor microenvironment.Parts of these cells in gliomas are derived from central nervous system microglia and circulating monocytes,and have been implicated in angiogenesis,immunosuppression,tumor progression and invasion of gliomas.This article reviews the potential mechanisms of TAM promoting glioma development through various pathways to provide new possibilities for targeted therapy of gliomas.

关 键 词：神经胶质瘤 巨噬细胞 免疫抑制法 肿瘤侵润 

分 类 号：R739.41[医药卫生—肿瘤]