基质金属蛋白酶及其抑制剂与口腔扁平苔藓相关性研究进展  

Progress in the correlation of matrix metalloproteinases and their inhibitors with oral lichen planus

作　　者：张紫欣 刘雪 ZHANG Zixin;LIU Xue(School of Stomatology,Jining Medical University,Jining 272000,China)

机构地区：[1]济宁医学院口腔医学院,济宁272013

出　　处：《济宁医学院学报》2021年第2期124-127,134,共5页Journal of Jining Medical University

基　　金：2020年山东省大学生创新创业训练计划项目(S202010443033);2020年济宁医学院大学生创新训练计划项目(cx2020073)。

摘　　要：口腔扁平苔藓(oral lichen planus,OLP)是一种常见的慢性炎症性口腔黏膜疾病,其确切病因尚不明确且具有一定癌变概率。基质金属蛋白酶(matrix metalloproteinase,MMPs)及其抑制剂在非特异性免疫病理性反应机制、炎症反应机制中发挥重要作用,提示其可能对OLP的发生发展有着重要作用。本文就MMPs及其抑制剂与OLP的相关性研究进展做一综述。Oral lichen planus is a common chronic inflammatory disease of oral mucosa,the exact etiology of which is still unclear and has a certain carcinogenic potential.Matrix metalloproteinases and their inhibitors play an important role in non-specific immunopathological response mechanisms and inflammatory response mechanisms,suggesting that they may be important in the development of oral lichen planus.This paper will review the progress of the correlation of matrix metalloproteinases and their inhibitors with oral lichen planus.

关 键 词：基质金属蛋白酶 金属蛋白酶组织抑制剂 口腔扁平苔藓 

分 类 号：R735.5[医药卫生—肿瘤]