碱基切除修复基因多态性与肿瘤相关性研究进展  

Research progress in the association between polymorphisms of base excision repair-associated genes and cancer

作　　者：刘邦全 胡元婷 徐丽丹[1,2] 张学龙 乔远东[1,2] Liu Bangquan;Hu Yuanting;Xu Lidan;Zhang Xuelong;Qiao Yuandong(Laboratory of Medical Genetics,Harbin Medical University,Harbin 150081,China;Key laboratory of preservation of human genetic resources and disease control in China(Harbin Medical University),Ministry of Education,Harbin 150081,China)

机构地区：[1]哈尔滨医科大学医学遗传学研究室,150081 [2]中国遗传资源保护与疾病防控教育部重点实验室(哈尔滨医科大学),150081

出　　处：《国际遗传学杂志》2021年第1期40-47,共8页International Journal of Genetics

基　　金：黑龙江省自然科学基金(D2007-04);黑龙江省政府博士后科研启动金(LBH-Q11029);国家自然科学基金(81102278、81373220)。

摘　　要：DNA损伤修复机制在维持基因组完整性方面起着至关重要的作用,其中碱基切除修复(base excision repair,BER)是修复活性氧引起的内源性DNA损伤的主要机制。碱基切除核心基因的基因多态性,会影响编码蛋白功能,降低DNA损伤修复的能力,并增加特定人群的患肿瘤风险。此文主要就碱基切除修复基因多态性在肿瘤中的研究进展作一综述。DNA damage repair mechanisms play a crucial role in maintaining the stability of the genome.Base excision repair(BER)is the main mechanism for repairing endogenous DNA damage caused by reactive oxygen species.The polymorphisms in BER core genes affect the function of encoded proteins,reduce the ability of DNA damage repair,and increase the risk of cancer in certain populations.This article reviews the progress in the study on gene polymorphism in BER in tumors.

关 键 词：碱基切除修复 肿瘤 基因多态性 

分 类 号：R730.2[医药卫生—肿瘤]