胆管癌发生和发展中重要分子及其作用机制的研究进展  

Research progress on important molecules and their mechanisms underlying the occurrence and development of cholangiocarcinoma

作　　者：颜丙芳 柏雪莲 孟玮[1] Yan Bingfang;Bai Xuelian;Meng Wei(Clinical Medicine Laboratory,Binzhou Medical University Hospital,Binzhou 256603,China)

机构地区：[1]滨州医学院附属医院临床医学实验室,256603

出　　处：《国际遗传学杂志》2021年第1期48-53,共6页International Journal of Genetics

基　　金：山东省医药卫生科技发展计划(2017WS884);滨州医学院科研计划与科研启动基金(BY2017KYQD12)。

摘　　要：胆管癌是一种原发性肝胆恶性肿瘤,起病隐匿,早期诊断困难,预后差。由于缺乏特异性早期诊断标记物及靶向治疗的分子靶点,胆管癌确诊时往往已是晚期,治疗效果欠佳。近年来,由于对胆管癌的研究不断深入,一些关键分子在胆管癌中的表达特点及其作用机制逐渐被发现和阐明,为胆管癌的分子靶向治疗提供了新依据。本文就近年来在胆管癌发生和发展中发挥重要作用的分子进行综述。Cholangiocarcinoma is a primary hepatobiliary malignant tumor with concealed onset,difficulty in early diagnosis and poor prognosis.Due to the lack of specific early diagnostic markers and molecules for targeted therapy,cholangiocarcinoma is often diagnosed in the late stage,and the treatment often fails.In recent years,with further investigation of cholangiocarcinoma,the expression and functional mechanism of some key molecules have been studied,which provides a new basis for molecular targeted therapy of cholangiocarcinoma.This article reviews the research progress in some important molecules of cholangiocarcinoma.

关 键 词：胆管癌 分子靶点 机制 

分 类 号：R735.8[医药卫生—肿瘤]