斯钙素在甲胎蛋白阳性胃癌组织中的表达及对预后的预测价值研究  

Expression of stanniocalcin-2 in AFP positive gastric cancer and its prognostic value

作　　者：黄林飞[1] 潘晟[1] 夏甘霖 朱磊[1] HUANG Linfei;PAN Sheng;XIA Ganlin(Department of Gastrointestinal Surgery,Wuhan Puren Hospital Affiliated to Wuhan University of Science and Technology,Wuhan 430080,China)

机构地区：[1]武汉科技大学附属武汉市普仁医院胃肠外科,430080

出　　处：《临床外科杂志》2021年第2期148-150,共3页Journal of Clinical Surgery

基　　金：2018年武汉市医学科研项目西医药类-青年项目(WX18Y08)。

摘　　要：目的研究斯钙素(STC2)在AFP阳性胃癌组织中的表达及对预后的预测价值。方法 2018年3月~2019年6月我院收治的甲胎蛋白(AFP)阳性胃癌病人112例,对照组112例,对癌旁组织、癌症组织以及正常黏膜的STC2表达情况进行检测,分析不同病理状态STC2表达情况的差异,分析STC2阳性表达与不同肿瘤组织分化程度、浸润程度、淋巴转移情况、腹腔转移情况之间的相关性。结果 STC2表达阳性率从高到低依次为癌症组织、癌旁组织以及正常黏膜组织,不同肿瘤组织分化程度、浸润程度、淋巴转移情况、腹腔转移情况之间的差异存在统计学意义(P<0.05);STC2表达阳性与不同肿瘤组织分化程度、浸润程度、淋巴转移情况、腹腔转移情况呈现正相关。结论 STC2在AFP阳性胃癌组织中的表达及与病人的肿瘤的预后呈现显著相关。Objective To study the expression of stc2 in AFP positive gastric cancer and its prognostic value.Methods Taking 112 AFP positive gastric cancer patients admitted to our hospital from March 2018 to June 2019 as the research object, another 112 normal gastric cancer patients in the same period of physical examination in our hospital as the control group, respectively, to compare the expression of stc2 in cancer tissues, cancer tissues and normal mucosa, analyze the difference between the expression of stc2 in cancer tissues with different disease states, and compare the expression of stc2 with the expression of stc2 The correlation among the degree of differentiation, infiltration, lymph node metastasis and peritoneal metastasis was analyzed.Results By comparing the expression of stc2 in three groups of tissues, the positive rate of stc2 from high to low was cancer tissue, paracancer tissue and normal mucosa tissue. By comparing the expression of stc2 in different pathological state of cancer tissue, there were statistically significant differences between the differentiation degree, infiltration degree(P<0.05);lymphatic metastasis and abdominal metastasis of different tumor tissue by correlation analysis, the positive expression of TC2 was positively correlated with the differentiation degree, infiltration degree, lymph metastasis and abdominal metastasis of different tumor tissues.Conclusion The expression of stc2 in AFP positive gastric cancer tissue is significantly related to the prognosis of the patients.

关 键 词：胃癌 浸润程度 淋巴转移情况 腹腔转移 斯钙素 

分 类 号：R735.2[医药卫生—肿瘤]