红球藻虾青素与炎症反应和肺部疾病的研究进展  

Research progress of the astaxanthin from Haematococcus pluvialis in inflammation and lung diseases

作　　者：刘建国[1,2,4] 李虎 张孟洁[1,2,3] 于文杰 栾维迎 LIU Jianguo;LI Hu;ZHANG Mengjie;YU Wenjie;LUAN Weiying(Key Laboratory of Experimental Marine Biology,Center for Ocean Mega-Science,Institute of Oceanology,Chinese Academy of Sciences,Qingdao 266071,China;Marine Biology and Biotechnology Laboratory,Pilot National Laboratory for Marine Science and Technology(Qingdao),Qingdao 266237,China;University of Chinese Academy of Sciences,Beijing 100047,China;National-Local Joint Engineering Research Center for Haematococcus pluvialis and Astaxanthin Products,Chuxiong 675012,China)

机构地区：[1]中国科学院海洋研究所海洋大科学中心,实验海洋生物学重点实验室,青岛266071 [2]青岛海洋科学与技术试点国家实验室,海洋生物学与生物技术功能实验室,青岛266237 [3]中国科学院大学,北京100047 [4]红球藻种质培育与虾青素制品开发国家地方联合工程中心,楚雄675012

出　　处：《生物学杂志》2021年第2期8-12,共5页Journal of Biology

基　　金：中国科学院战略性先导科技专项B类(XDB42000000);国际合作计划(GJHZ2039)项目;国家自然科学基金(U1706209)。

摘　　要：概述红球藻虾青素与炎症反应和肺部疾病的研究进展,介绍虾青素通过各种不同通路(如核转录因子、肿瘤坏死因子、白介素、干扰素、T和B细胞等)降低促炎因子水平、促进抑制炎症因子的产生、维持促炎症因子与抑制炎症因子之间的动态平衡从而避免炎症过激反应与机体损伤发生的作用;介绍虾青素改善急性肺损伤、减轻肺纤维化、抑制肺癌等功能性作用,展望虾青素作为新型生物制品对预防/延缓和减轻炎症反应和肺部疾病以及加快身体康复的前景。This article summarizes the research progress of astaxanthin in treatment of the inflammation and lung diseases,introduces that astaxanthin can reduce the production of pro-inflammatory factors,inhibit inflammation,or increase the production of anti-inflammatory factors through various pathways(such as nuclear transcription factor,tumor necrosis factor,interleukin,interferon,T and B cells,etc.)and maintain the dynamic balance between pro-inflammatory factors and anti-inflammatory factors to avoid excessive inflammatory reaction and damage;in addition,astaxanthin has functional effects such as improving acute lung injury,reducing lung fibrosis,and inhibiting lung cancer.The prospect of astaxanthin as a new type of biological product for preventing/delaying and reducing inflammation and lung diseases as well as accelerating physical rehabilitation is prospected.

关 键 词：红球藻 虾青素 炎症反应 肺部疾病 

分 类 号：Q562[生物学—生物化学] R563[医药卫生—呼吸系统]