血清皮质醇、DHEA-S、急性时相反应蛋白、甲状腺激素与精神分裂症患者精神症状的相关性  

Association of serum cortisol, DHEA-S, acute phase response protein, thyroid hormone with psychiatric symptoms of patients with schizophrenia

作　　者：王旭东 陈勇华 李晓一[2] WANG Xudong;CHEN Yonghua;LI Xiaoyi(Department of Psychiatry,Zhoushan Second People's Hospital,Zhoushan 316000,China)

机构地区：[1]舟山市第二人民医院精神科,316000 [2]浙江省立同德医院精神科

出　　处：《浙江医学》2021年第7期730-734,共5页Zhejiang Medical Journal

基　　金：舟山市科技局计划项目(2018C31123)。

摘　　要：目的探讨血清皮质醇、硫酸脱氢表雄酮水平(DHEA-S)、急性时相反应蛋白、甲状腺激素与精神分裂症患者精神症状的相关性。方法选取2017年8月至2019年12月舟山市第二人民医院精神科收治的130例精神分裂症患者(研究组)和本院健康体检者140例(对照组),收集两组对象一般资料,采用阳性与阴性症状量表(PANSS)进行评分,测定血清皮质醇、DHEA-S、急性时相反应蛋白、甲状腺激素水平,并采用Pearson相关分析血清皮质醇、DHEA-S、急性时相反应蛋白、甲状腺激素与患者精神症状的相关性。结果研究组阴性量表、阳性量表、一般病理量表及总分均高于对照组,差异均有统计学意义(P<0.05)。研究组血清皮质醇、DHEA-S及皮质醇/DHEA-S比值均高于对照组,差异均有统计学意义(均P<0.05)。研究组铜蓝蛋白(CER)、CRP及α1-酸性糖蛋白(AAG)均高于对照组,转铁蛋白(TRF)低于对照组,差异均有统计学意义(均P<0.05)。研究组促甲状腺激素(TSH)、T3、T4、FT4均高于对照组,FT3低于对照组,差异均有统计学意义(均P<0.05)。皮质醇、DHEA-S、CER、CRP、TRF、AAG、TSH、T3、T4、FT3、FT4与精神分裂症患者阳性症状、一般病理症状评分、病史均无相关性(均P>0.05);皮质醇、DHEA-S、CER、CRP、TRF、AAG、TSH、T3、T4、FT3、FT4与精神分裂症患者阴性症状均呈正相关,皮质醇、DHEA-S与发病年龄、年龄均呈正相关(均P<0.05)。结论皮质醇、DHEA-S、急性时相反应蛋白、甲状腺激素水平与精神分裂症患者精神症状密切相关,其水平可作为精神分裂症诊断及治疗有效性监测的生物学标志物。Objective To investigate the association of serum cortisol,dehydroepiandrosterone sulfate(DHEA-S),acute phase response protein(ARP),thyroid hormone with psychiatric symptoms of patients with schizophrenia.Methods One hundred and thirty patients with schizophrenia admitted to the psychiatric department of Zhoushan Second People’s Hospitalfrom August 2017 to December 2019(study group),and 140 healthy subjects(control group)were enrolled in the study.The general data were collected and scored using the Positive and Negative Symptom Scale(PANSS).Serum cortisol,DHEA-S,ARP,and thyroid hormone levels were measured,and Pearson regression was used to analyze the association of serum cortisol,DHEA-S,ARP,thyroid hormones and mental symptoms with symptoms of patients with schizophrenia.Results The negative scale,positive scale,general pathology scale and total scores ofthe study group were higher than those ofthe control group(P<0.05).The serum cortisol,DHEA-S levels and the ratio of cortisol/DHEA-S in the study group were higher than those in the control group(all P<0.05).Serum ceruloplasmin(CER),C-reactive protein(CRP)andα1-acid glycoprotein(AAG)levels in the study group were higher than those in the control group,and trans fe rrin(TRF)was lower than that in the control group(all P<0.05).Thyroid-stimulating hormone(TSH),triiodothyronine(T3),tetraiodothyronine(T4),and free thyroxine(FT4)in the study group were all higher than those in the control group,and FT3 was lower than that in the control group(all P<0.05).Cortisol,DHEA-S,CER,CRP,TRF,AAG,TSH,T3,T4,FT3,FT4 were not correlated with positive symptoms,general pathological symptom scores,and medical history(all P>0.05).Cortisol,DHEA-S,CER,CRP,TRF,AAG,TSH,T3,T4,FT3,FT4 were positively correlated with negative symptoms.Cortisol and DHEA-S were positively correlated with the age of onset and age of patients(all P<0.05).Conclusion The levels of cortisol,DHEA-S,acute phase response protein,and thyroid hormone are closely related to the psychiatric symptoms of patients with s

关 键 词：血清皮质醇 硫酸脱氢表雄酮水平 急性时相反应蛋白 甲状腺激素 精神分裂症 

分 类 号：R749.3[医药卫生—神经病学与精神病学]