血府逐瘀汤联合艾司奥美拉唑镁肠溶片对胃食管反流病气滞血瘀证的疗效观察  

Observation on the Efficacy of XuefuZhuyu Decoction plus Esomeprazole Enteric-coated Tablets in the Treatment of Gastroesophageal Reflux Disease with Qi Stagnation and Blood Stasis Syndrome

作　　者：田明[1] 孙清露[2] Tian Ming;Sun Qinglu(Department of General Surgery,Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine,Beijing 100700,China;Department of Pediatrics,Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine,Beijing 100700,China)

机构地区：[1]北京中医药大学东直门医院普外科,100700 [2]北京中医药大学东直门医院儿科,100700

出　　处：《中华胃食管反流病电子杂志》2020年第3期139-143,共5页Chinese Journal Of Gastroesophageal Reflux Disease(Electronic Edition)

基　　金：北京中医药大学青年教师项目(2018-JYBZZ-JS081)。

摘　　要：目的观察血府逐瘀汤联合艾司奥美拉唑镁肠溶片治疗胃食管反流病(GERD)气滞血瘀证的效果。方法选取GERD气滞血瘀证患者62例,随机分为对照组(32例)和治疗组(30例)。对照组患者单纯给予艾司奥美拉唑镁肠溶片,治疗组患者给予血府逐瘀汤联合艾司奥美拉唑镁肠溶片,疗程均为8周。使用反流性疾病问卷(RDQ)积分分别评估治疗前后GERD食管症状的严重程度;使用气滞血瘀证量表积分分别评估治疗前后气滞血瘀证的严重程度。采用Fisher确切概率法检验两组患者食管症状和气滞血瘀证的治疗有效率。结果两组患者治疗前RDQ积分和气滞血瘀证量表积分差异均无统计学意义(P>0.05)。食管症状的改善方面,治疗组的有效率为86.2%,对照组的有效率为58.1%,治疗组优于对照组(P<0.05);气滞血瘀证的改善方面,治疗组的有效率为93.1%,对照组的有效率为67.7%,治疗组优于对照组(P<0.05)。结论与艾司奥美拉唑镁肠溶片单用相比,血府逐瘀汤联合艾司奥美拉唑镁肠溶片对GERD气滞血瘀证具有更好的治疗作用。Objective To investigate the efficacy of XuefuZhuyu Decoction plus esomeprazole enteric-coated tablets in the treatment of gastroesophageal reflux disease(GERD)with Qi Stagnation and Blood Stasis syndrome.Methods Totally 62 patientswith GERD with Qi Stagnation and Blood Stasis syndrome were randomly dividedinto two groups:control group(32 cases)and treatment group(30 cases).Patients in the control group were given esomeprazole enteric-coated tablets for 8 weeks,and patients in the treatment group were given both XuefuZhuyu Decoction and esomeprazole enteric-coated tablets for 8 weeks.Before and after treatment,the two groupswere scored using the Reflux Diagnostic Questionnaire(RDQ)and Diagnosis Scale for Qi Stagnation and Blood Stasis Syndrometo evaluate the esophageal symptoms and Qi Stagnation and Blood Stasis syndrome.The effective rateonthe esophageal symptoms and Qi Stagnation and Blood Stasis syndrome were compared between two groups.Results There were no significant differences comparing the scores of RDQ(P>0.05)and Diagnosis Scale for Qi Stagnation and Blood Stasis Syndrome(P>0.05).For esophageal symptoms,the effective rate was 86.2% in the treatment group,versus 58.1% in the control group;for Qi Stagnation and Blood Stasis syndrome,the effective rate was 93.1% in the treatment group,versus 67.7% in the control group.Conclusion In comparison with esomeprazole enteric-coated tabletsonly,XuefuZhuyu Decoction plus esomeprazole enteric-coated tablets have better efficacy on GERD with Qi Stagnation and Blood Stasis syndrome.

关 键 词：气滞血瘀证 胃食管反流病 血府逐瘀汤 

分 类 号：R571[医药卫生—消化系统]