胃食管反流相关性慢性咳嗽并咽喉反流患者的反流特征  

Analysis of reflux characteristics in patients with gastroesophageal reflux associated chronic cough and laryngopharyngeal reflux

作　　者：阿里木·买买提[1] 陶发明 祖里培亚·艾拜都拉[2] 吴朝阳[1] 克力木·阿不都热依木[3] Alimu·Maimaiti;Tao Faming;Zulipeiya·Aibaidoula;Wu Zhaoyang;Kelimu·Abudureyimu(Derartment of Emergency and Traumatic Surgery,People's Hospital of Xinjiang Uygur Autonomous Region,Urumqi 830001,China;Department of Respiratory Medicine,People's Hospital of Xinjiang Uygur Autonomous Region,Urumqi 830001,China;Department of Minimally Invasive Surgery,Hernia and Abdominal Wall Surgery,People's Hospital of Xinjiang Uygur Autonomous Region,Urumqi 830001,China)

机构地区：[1]新疆维吾尔自治区人民医院急诊创伤外科,乌鲁木齐830001 [2]新疆维吾尔自治区人民医院呼吸与危重症医学中心,乌鲁木齐830001 [3]新疆维吾尔自治区人民医院微创,疝和腹壁外科,乌鲁木齐830001

出　　处：《中华胃食管反流病电子杂志》2020年第3期172-176,共5页Chinese Journal Of Gastroesophageal Reflux Disease(Electronic Edition)

基　　金：新疆维吾尔自治区自然科学基金(2018D01C134)。

摘　　要：目的探讨胃食管反流相关性慢性咳嗽(GERC)并伴喉咽反流(LPR)患者的反流特征。方法选取2019年1月至2019年6月间在新疆维吾尔自治区人民医院住院收治的60例慢性咳嗽患者。对所有患者进行反流症状指数(RSI)问卷调查,分析咳嗽症状评分以及高分辨率食管测压和24 h pH监测。结果按照食管24 h pH监测反流次数、酸暴露时间百分比及DeMeester评分,对患者进一步分为非酸性GERC组(n=32)和酸性GERC组(n=28)。在非酸性GERC组中,RSI评分25.00(8.00)显著高于酸性GERC组16.00(6.50),且差异有统计学意义(Z=-3.105,P<0.05)。此外,非酸性GERC患者的“持续清嗓”和“呼吸困难或窒息发作”比酸性GERC患者更明显。结论LPR与GERC部分重叠,RSI评分较高的非酸性GERC患者可能表现出更多的非酸性反流和呼吸困难。Objective To investigate the characteristics of gastroesophageal reflux associated chronic cough(GERC)with laryngopharyngeal reflux(LPR).Methods According to the criteria of inclusion,exclusion and diagnosis,a total of 60 patients with chronic cough who were hospitalized in the people's Hospital from January 2019 to June 2019 were selected as the study group,and the refluxsymptom index(RSI)questionnaire survey,cough symptom score,high-resolution esophageal manometry and 24-hour pH monitoring were conducted to analyze reflux characteristics.Results After analysis of 24 h pH monitoring,the number of reflux,the percentage of acid exposure time and DeMeester score the patients were further divided into two groups:non acid GERC group(n=32)and acidic GERC group(n=28).In non acid GERC group,the RSI score was significantly higher than that of acid GERCgroup[25.00(8.00)vs 16.00(6.50);Z=-3.105,P=0.001].In addition,the scores of"continuous voice clearing"and"dyspnea or asphyxia attack"in non acid GERC patients were more significant than those in acidicGERC patients.Conclusion The patients with LPR and GERC was partially overlapped,and the patients with higher RSI may show more non acid reflux and dyspnea.

关 键 词：慢性咳嗽 胃食管反流性咳嗽 反流症状指数 

分 类 号：R571[医药卫生—消化系统] R766[医药卫生—内科学]