Application of germ-free NOD-scid IL2rg^(null)mice as a humanized model for tumor microbiome precision medicine  

作　　者：Chengwei Wu Haitao Shang Xianhong Jiang Xinning Wang Hong Wei 

机构地区：[1]Precision Medicine Instiute,The First Afiliated Hospital,Sun Ya-sen University,Guangzhou 510080,China [2]College of Animal Sciences and Technology,Slate Key Laboratory of Agricultural Microbiology,Huazhong Agriculnural University,Wuhan 430070,China

出　　处：《Science China(Life Sciences)》2021年第4期644-647,共4页中国科学（生命科学英文版）

基　　金：supported by grants from the National Key Research and Development Program of China(2017YFD0500503,2017YFD0501000);the National Natural Science Foundation of China(81770434,81370906);the National Program on Key Basic Research Project of China(973 Program)(2007CB513007,2013CB531406)。

摘　　要：In 2013,tumor immunotherapy topped the list of the top ten scientific breakthroughs(Couzin-Frankel,2013),and it was widely used in the treatment of lung cancer,kidney cancer,and melanoma(Routy et al.,2018).However,the response rate of patients to tumor immunotherapy varies,and usually,only a small percentage of patients respond well to treatment(Sambi et al.,2019).

关 键 词：al. LUNG cancer 

分 类 号：R73-36[医药卫生—肿瘤]