Quaterrylene-环糊精肿瘤光热治疗剂的大鼠肾-尿代谢研究  

Renal clearance of a photothermal therapy agent based on quaterrylene-cyclodextrin conjugates

作　　者：李金梅[1] 罗亚丽 王克让[2] LI Jinmei;LUO Yali;WANG Kerang(Department of Pathology,The First Central Hospital of Baoding,Baoding 071000,China;Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry of Education,College of Chemistry and Environmental Science,Hebei University,Baoding 071002,China)

机构地区：[1]保定市第一中心医院病理科,河北保定071000 [2]河北大学化学与环境科学学院,药物化学与分子诊断教育部重点实验室,河北保定071002

出　　处：《河北大学学报（自然科学版）》2021年第2期166-170,共5页Journal of Hebei University(Natural Science Edition)

基　　金：河北大学药物化学与分子诊断教育部重点实验室提升计划(ts2019002);保定市科技局项目(17ZF220)

摘　　要：光热治疗(photothermal therapy,PTT)是将光能转化为热能而达到治疗效果的一种新的治疗手段,然而代谢问题是其临床应用研究亟待解决的关键问题.基于quaterrylene-环糊精衍生物(QDI-CD)良好的光热治疗效果,研究了其在sprague-dawley(SD)大鼠中的代谢情况,发现给药量为1 mg/只时,QDI-CD的平均代谢率为(48.74±11.80)%.将SD大鼠尿液经分离后,高分辨质谱(HRMS)结果显示QDI-CD分子的结构与代谢前一致.Photothermal therapy(PTT)is a promising avenue for precision cancer treatment.However,the metabolic clearance is a key issue for future clinical applications.In this paper,renal clearance of a cyclodextrin-modified quaterrylene bisimide derivative(QDI-CD)was studied.Importantly,QDI-CD administered to sprague-dawley(SD)rats by intraperitoneal injection was effectively cleared with renal clearance efficiency of(48.74±11.80)%at 12 h after drug injection.In addition,the structure of QDI-CD in urines did not changed under the metabolism.

关 键 词：光热治疗 代谢 环糊精 quaterrylene 

分 类 号：R73-37[医药卫生—肿瘤] R962[医药卫生—临床医学]