鼻血管瘤患者术后医院感染与炎症因子水平的相关性研究  

Correlation Research between Inflammatory Factors,Immune Factors and Postoperative Hospital Infection of Nasal Angioma

作　　者：许金中 王真[1] 王海玲[1] XU Jinzhong;WANG Zhen;WANG Hailing(The Second People's Hospital of Jiyuan,Jiyuan,459000)

机构地区：[1]济源市第二人民医院,459000

出　　处：《实用癌症杂志》2021年第4期598-601,共4页The Practical Journal of Cancer

基　　金：河南省医学科技攻关计划项目(编号:2017082135)。

摘　　要：目的探讨鼻血管瘤患者术后医院感染与炎症因子水平的相关性,为鼻血管瘤患者术后医院感染的防治提供参考。方法选取行鼻内镜下低温等离子手术治疗鼻血管瘤术后发生医院感染的30例为研究对象(感染组),以1∶2的比例随机选取同期行鼻内镜下低温等离子手术治疗鼻血管瘤术后未发生医院感染的60例为对照(无感染组),对感染患者用无菌棉试子采集感染部位分泌物进行病原菌分离、培养、菌株鉴定,检测两组患者血清白细胞介素-6(IL-6)、白细胞介素-8(IL-8)、肿瘤坏死因子α(TNF-α)、C反应蛋白(CRP)、T淋巴细胞亚群(CD3、CD4、CD8、CD4/CD8)水平,观察结果。结果30例医院感染患者,其中呼吸道感染21例、泌尿道感染6例、皮肤黏膜感染3例,分别占70.00%、20.00%、10.00%,总检出病原菌21株,其中革兰阴性菌16例、革兰阳性菌5株,分别占76.29%、33.71%;血清IL-6、IL-8、TNF-α、CRP水平感染组分别为(29.12±5.54)ng/ml、(28.05±3.66)ng/ml、(8.63±3.32)ng/ml、(14.27±5.51)mg/l,高于无感染组(14.97±4.81)ng/ml、(15.21±4.02)ng/ml、(2.35±0.92)ng/ml、(6.25±2.35)mg/l,比较差异有统计学意义(P<0.05);血清CD3、CD4、CD4/CD8水平感染组分别为(48.45±1.38)%、(34.15±1.23)%、(1.11±0.13),低于无感染组(50.97±1.56)%、(35.91±1.39)%、(1.25±0.20),CD8水平感染组为(33.85±2.67)%,高于无感染组(28.42±2.87),比较差异有统计学意义(P<0.05)。结论鼻血管瘤患者术后容易发生呼吸道感染,感染病原菌主要为革兰阴性菌,术后发生医院感染的患者血清炎症因子明显增高,同时存在免疫功能的异常。Objective To discuss the correlation research between inflammatory factors and postoperative hospital infection of nasal angioma,and to provide a reference for the prevention and treatment of postoperative hospital infection with nasal angioma.Methods 30 cases of patients with postoperative hospital infection(infection group)for Low temperature plasma surgery under nasal endoscope in the treatment of nasal angioma,60 cases of patients with postoperative hospital infection(non infection group)in randomly selected in a ratio of 1∶2.Pathogenic bacteria were isolated,cultured and identified of infection patients,to detection of serum interleukin-6(IL-6)and interleukin-8(IL-8),tumor necrosis factor alpha(TNF-a),c-reactive protein(CRP),T lymphocyte subsets(CD3,CD4,CD8 and CD4/CD8)level of the two groups.Results There were 21 cases of respiratory tract infection(70.00%),6 cases of urinary tract infection(20.00%)and 3 cases of skin mucosa infection(10.00%),21 strains of pathogenic bacteria,there were 16 cases of gram-negative bacteria(76.29%)and 5 strains of gram-positive bacteria(33.71%).IL-6 were(29.12±5.54)ng/ml,IL-8 were(28.05±3.66)ng/ml,TNF-αwere(8.63±3.32)ng/ml,CRP were(14.27±5.51)mg/l of the infection group,IL-6 were(14.97±4.81)ng/ml,IL-8 were(15.21±4.02)ng/ml,TNF-αwere(2.35±0.92)ng/ml,CRP were(6.25±2.35)mg/l of the non infection group,the difference was not statistically significant(P<0.05).CD3 were(48.45±1.38)%,CD4 were(34.15±1.23)%,,CD8 were(33.85±2.67)%,CD4/CD8 were(1.11±0.13)of the infection group,CD3 were(50.97±1.56)%,CD4 were(35.91±1.39)%,CD8 were(33.85±2.67)%,CD4/CD8 were(1.25±0.20)of the non infection group,the difference was not statistically significant.Conclusion Respiratory infection is easy of postoperative patients with nasal angioma,the main pathogen of infection is gram-negative bacteria,had significantly higher serum inflammatory factors and abnormal immune function of patients with postoperative hospital infection.

关 键 词：鼻血管瘤 医院感染 炎症因子 

分 类 号：R739.62[医药卫生—肿瘤]