中性粒细胞/淋巴细胞比值在外阴鳞癌和外阴上皮内瘤变筛查中的预测价值  

Prognostic significance of neutrophil-lymphocyte ratio in vulvar squamous cell carcinoma and vulvar intraepithelial neoplasia

作　　者：熊巍[1] 王丹[1] 王瑾晖[1] 张颖[1] 曹冬焱[1] XIONG Wei;WANG Dan;WANG Jinhui;ZHANG Ying;CAO Dongyan(Department of Obstetrics and Gynecology,Peking Union Medical College Hospital,Beijing 100730,China)

机构地区：[1]北京市协和医院妇产科,北京100730

出　　处：《实用肿瘤学杂志》2021年第2期125-130,共6页Practical Oncology Journal

摘　　要：目的本研究旨在探讨中性粒细胞/淋巴细胞比值(NLR)与外阴病变活检病理的关系,并探讨NLR能否作为鉴别外阴鳞癌与其癌前病变外阴上皮内瘤变的炎症标志物的可行性。方法回顾分析2012年12月—2020年6月386例因外阴病变进行活检的患者,评估术前NLR与外阴病变的病理结果的相关性。结果外阴鳞癌组的平均NLR明显高于外阴上皮内瘤变组。多因素分析表明,NLR升高、年龄和肿瘤大小与外阴鳞癌密切相关,其中NLR升高病理活检为外阴鳞癌的风险最高(OR=4.84,95%CI4.17~7.14,P<0.001)。ROC曲线提示,从外阴上皮内瘤变检测出外阴鳞癌的NLR分界值为3.01,敏感性为88.2%,特异性为67.8%。结论NLR有望作为鉴别外阴鳞癌和外阴上皮内瘤变的生物学标志物,并有助于外阴病变的判断。Objective The aim of this study is to evaluate whether neutrophil-lymphocyte ratio(NLR)is associated with vulvar biopsy pathology,and to examine whether NLR can be used as an inflammatory marker to differentiate vulvar squamous cell carcinoma(VSCC)from its precancerous lesion vulvar intraepithelial neoplasia(VIN).Methods A retrospective study was performed on 386 patients undergoing vulvar biopsy from December 2012 to June 2020.The correlation between preoperative NLR and the biopsy pathologic findings were evaluated.Results The mean NLR of the patients with VSCC was significantly higher than that of the patients with VIN.The cut-off value of NLR in detecting VSCC from VIN selected on the ROC curve was 3.01 with 88.2%sensitivity and 67.8%specificity.Multivariate analysis identified an elevated NLR,age,and tumor size were associated with the presence of vulvar carcinoma and patients with elevated NLR have the highest risk of VSCC(OR=4.84,95%CI4.17~7.14,P<0.001).Conclusion NLR may be a useful marker to differentiate VSCC from VIN,and it may help in decision making(pre)cancerous pathologies of the vulvar.

关 键 词：中性粒细胞/淋巴细胞比值 预测 外阴鳞癌 外阴上皮内瘤变 

分 类 号：R737.5[医药卫生—肿瘤]