Notch信号通路调控肿瘤细胞凋亡机制研究进展  

Research progress of Notch signaling pathway in regulating apoptosis of tumor cells

作　　者：尹琦 胡彦建 崔普泽(综述) 胡彦华(审校)[1] YIN Qi;HU Yanjian;CUI Puze;HU Yanhua(Department of General Surgery,The Second Affiliated Hospital of Harbin Medical University,Harbin 150081,China;Gastroenterology and Hepatology,Harbin First Hospital of Affiliated to Harbin Institute of Technology)

机构地区：[1]哈尔滨医科大学附属第二医院普通外科,哈尔滨150081 [2]哈尔滨工业大学附属哈尔滨市第一医院消化内科

出　　处：《实用肿瘤学杂志》2021年第2期165-169,共5页Practical Oncology Journal

基　　金：黑龙江省博士后科研启动基金(编号:LBH-Q14110);黑龙江省卫生计生委科研课题(编号:2018-347)。

摘　　要：Notch信号通路在许多肿瘤细胞中异常表达,因其高表达相关性,表现为原癌或抑癌基因作用。当肿瘤细胞因外部刺激或细胞内信号影响Notch信号表达后,Notch信号通过与其他细胞信号通路的“串扰”,或直接调控凋亡蛋白,从而促进或抑制肿瘤细胞凋亡。本文综述了Notch信号通路促进和抑制肿瘤细胞凋亡及其作用机制,通过Notch信号通路在各种凋亡途径中的不同作用机制,为Notch信号通路抗肿瘤治疗提供理论支持。The abnormal expression of Notch signaling pathway in many tumor cells,due to its high background correlation,shows the role of proto-oncogene or tumor suppressor gene.When the expression of Notch signal is affected by external stimulation or intracellular signal,Notch signal can promote or inhibit tumor cell apoptosis through“crosstalk”with other cell signaling pathways or by directly regulating apoptotic proteins.This paper reviews the mechanism of Notch signaling pathway in promoting and inhibiting tumor cell apoptosis,and provides theoretical support for anti-tumor therapy of Notch signaling pathway through the different effects of Notch signaling pathway on various apoptosis pathways.

关 键 词：NOTCH信号通路 肿瘤细胞 凋亡 机制 

分 类 号：R730.2[医药卫生—肿瘤]