原癌小体所载蛋白及miRNAs在癌细胞转移第一阶段机制中的作用  

Role of oncosome-carried proteins and miRNAs in the first phase of metastasis

作　　者：丁亦瑶 谢丁祺 于夕淼 李淼 包宇涵 王全明[3] 丁磊 DING Yiyao;XIE Dingqi;YU Ximiao;LI Miao;BAO Yuhan;WANG Quanming;DING Lei(Deparment of Basic Medical Sciences,Wuxi College of Medicine,Jiangnan University,Wuxi 214122,China;School of Humanities,Jiangnan University,Wuxi 214122,China;Deparment of Orthopaedic Surgery,Affiliated Hospital of Jiangnan University,Wuxi 214062,China)

机构地区：[1]江南大学无锡医学院基础医学系,江苏无锡214122 [2]江南大学人文学院,江苏无锡214122 [3]江南大学附属医院骨外科,江苏无锡214062

出　　处：《现代医学》2021年第2期228-232,共5页Modern Medical Journal

基　　金：2019年大学生创新训练计划国家级项目(1282050205195418);江苏省自然科学基金资助项目(BK20171143)。

摘　　要：原癌小体(oncosomes)特指癌细胞分泌的外泌体(tumor-derived exosomes)。它们是直径50~150 nm的囊泡样结构,可运载多种生物大分子,如癌蛋白、细胞因子、酶、聚糖、脂类、DNA和RNAs,经血液循环至目标细胞,实现远程细胞间联络,在癌细胞转移过程中发挥重要的作用。本文聚焦原癌小体所载运的蛋白质(尤其是膜蛋白)和miRNAs在癌细胞转移第一阶段所涉及的上皮细胞间质转化(endothelial-mesenchymal transition,EMT)的诱导、肿瘤血管微环境的调控、癌细胞转移方向的选择三方面所起的作用,通过使用检索词条"Oncosomes OR exosomes AND EMT""Oncosomes OR exosomes AND tumor vascular microenviroment"、"Oncosomes OR exosomes AND tumor organotropic metastasis",在PubMed查阅、分析、总结了近五年在这一有关肿瘤转移方面的研究进展。Oncosomes are cancer cell-derived exosomes referring to a group of extracellular vesicles ranging from50-150 nm in diameter.They are capable of transporting biological macromolecules,including oncoproteins,cytokines,enzymes,glycans,lipids,DNA and RNAs,to target cells via the vascular network.In this way,oncosomes bridge the long-distance communication between cancer cells and target cells and play crucial roles in metastasis.In this review,we focus on the role of oncosome-carried proteins,especially membrane proteins,and miRNAs in three aspects involved in the first-phase of metastasis,including epithelial-to-mesenchymal transition(EMT),regulation of tumor vascular microenviroment and tumor organotropic metastasis.Through searching PubMed with key words"Oncosomes OR exosomes AND EMT","Oncosomes OR exosomes AND tumor vascular microenvironment","Oncosomes OR exosomes AND tumor organotropic metastasis",we analyzed and summarized the major research progress in this field published in the past five years.

关 键 词：原癌小体 癌细胞转移 上皮细胞间质转化 肿瘤血管微环境 癌细胞转移定向 综述 

分 类 号：R73-37[医药卫生—肿瘤]