非小细胞肺癌化疗后温下方加减干预临床疗效研究  

Study on The Clinical Effects of Modified Warming Purging Prescription intervention after Chemotherapy for Non-small Cell Lung Cancer

作　　者：尹湘君 阮家钊 柴毅 季旭明 YIN Xiang-jun;RUAN Jia-zhao;CHAI Yi;JI Xu-ming(School of basic medicine,Zhejiang University of traditional Chinese medicine,Hangzhou 310053,China)

机构地区：[1]浙江中医药大学,浙江杭州310053

出　　处：《陕西中医药大学学报》2021年第2期75-79,共5页Journal of Shaanxi University of Chinese Medicine

基　　金：国家自然科学基金项目(81774198)。

摘　　要：目的观察非小细胞肺癌(non-small cell lung cancer,NSCLC)患者化疗后运用温下方加减的治疗效果。方法纳入NSCLC化疗后患者32例,核心病机均为阳气不足、寒凝瘀滞,运用温下方加减治疗并进行疗效评价。评价主要指标为:瘤灶近期疗效,临床症状评分,肺癌治疗功能评价量表(FACT-L)评分,卡氏(KPS)评分。结果治疗前后患者瘤灶近期疗效未见显著差异(P>0.05);温下方加减干预后患者临床症状总评分较前明显降低(P<0.01);肺癌治疗功能评价量表中,生理状况、功能状况、肺癌特异模块评分及总分较治疗前显著增加(P<0.05);KPS评分显示治疗后评分较治疗前显著升高(P<0.01)。结论温下方加减治疗NSCLC化疗后患者,可有效改善患者临床症状,提高患者生活质量。Objective To observe the therapeutic effect of modified warming purging prescription after chemotherapy in patients with non-small cell lung cancer(NSCLC).Methods 32 patients with NSCLC after chemotherapy were included in this study.The core pathogenesis was deficiency of Yang Qi,cold coagulation and blood stasis.The main outcome measures were short-term efficacy,clinical symptom score,FACT-L score and KPS score.Results There was no significant difference in the short-term curative effect of tumor focus before and after treatment(P>0.05);the total score of clinical symptoms was significantly lower than before(P<0.01);in the lung cancer treatment function evaluation scale,the physiological status,functional status,lung cancer specific module score and total score were significantly increased than before treatment(P<0.05);KPS score showed that the score after treatment was significantly higher than before treatment 01).Conclusion Modified warming purging prescription can effectively improve the clinical symptoms and quality of life of patients with NSCLC after chemotherapy.

关 键 词：非小细胞肺癌 化疗 温下方 临床疗效 阳虚寒凝 

分 类 号：R734[医药卫生—肿瘤]