长链非编码RNA在肝细胞性肝癌中的作用  

The role of long non-coding RNAs in hepatocellular carcinoma

作　　者：周艳[1] 陈超[1] 杨竹林[1] 熊力[1] ZHOU Yan;CHEN Chao;YANG Zhulin;XIONG Li(Department of General Surgery,the Second Xiangya Hospital,Central South University,Changsha 410011,China)

机构地区：[1]中南大学湘雅二医院普通外科,湖南长沙410011

出　　处：《中国普通外科杂志》2021年第3期349-356,共8页China Journal of General Surgery

基　　金：国家自然科学基金资助项目(81773293,81970569);湖南省交通运输厅科技进步与创新计划资助项目[湘交科教[2018]234号(201835)];湖南省科技厅重点研发基金资助项目(2015GK3117);湖南省中医药研究基金资助项目(201869,2011951);湖南省发展和改革委员会创新研发项目[湘发改投资(2019)875号];中南大学新型冠状病毒感染的肺炎防控首批应急资助项目[13400(160260007)]。

摘　　要：肝细胞型肝癌(HCC)是常见的消化系统恶性肿瘤,也是与癌症相关死亡的第三大主要原因,目前缺乏有效的治疗手段。长链非编码RNA(lncRNA)是一种长度超过200个核苷酸的非编码转录本。目前,lncRNA被认为在HCC的增殖、凋亡、转移、耐药及肿瘤干细胞的调节起重要作用。笔者结合该领域的最新研究进展概述了lncRNA的概念、特点和作用模式及其在HCC的发生、发展中的作用,以及基于lncRNA治疗HCC的探索。作为HCC发生的重要调节剂,lncRNA有希望作为HCC的诊断和治疗的潜在生物标志物和靶标。Hepatocellular carcinoma(HCC)is a common malignant tumor of digestive system,and the third leading cause of cancer-related death with no effective treatment available at present.Long non-coding RNAs(lncRNAs)are RNA molecules with a transcript length of more than 200 nt and lack a protein-coding ability.Currently,lncRNAs are considered to play important roles in proliferation,apoptosis,metastasis,drug resistance and cancer stem cells regulation of HCC.Combined with the latest research progress in this field,the authors address the concept,characteristics and action mode of lncRNAs and their actions in the occurrence and development of HCC,and the exploration of lncRNA-based treatment of HCC.As an important regulator of HCC,lncRNAs are promising biomarkers and targets for the diagnosis and treatment of HCC.

关 键 词：癌 肝细胞 RNA 长链非编码 肿瘤干细胞 综述 

分 类 号：R735.7[医药卫生—肿瘤]