微波热疗联合放化疗治疗进展期胃癌的临床疗效初步观察  

Preliminary observation of clinical efficacy of microwave hyperthermia combined with radiochemotherapy for locally advanced gastric cancer

作　　者：齐青 卢永昌[2] 霍忠超[1] 王丽[1] 苏英[1] 贺晓磊 李志加 王文玲 吕林林 周永乐 许斐 赵李伟 Qi Qing;Lu Yongchang;Huo Zhongchao;Wang Li;Su Ying;He Xiaolei;Li Zhijia;Wang Wenling;Lyu Linlin;Zhou Yongle;Xu Fei;Zhao Liwei(Department of Radiation Oncology,The Affiliated Hospital of Hebei Engineering University,Handan 056002,China;Handan First Hospital,Handan 056002,China)

机构地区：[1]河北工程大学附属医院肿瘤科,邯郸056002 [2]邯郸市第一医院,056002

出　　处：《中华放射肿瘤学杂志》2021年第4期368-371,共4页Chinese Journal of Radiation Oncology

基　　金：吴阶平医学基金项目(320.6750.17057)。

摘　　要：目的初步观察微波热疗联合调强放疗(IMRT)及化疗治疗进展期胃癌的临床疗效。方法选取不能手术或拒绝手术,经胃镜病理及影像学证实为局部晚期的近端或远端胃癌患者40例。IMRT总剂量为46~56Gy(中位数50Gy),1.8~2.0Gy/次,5次/周;同步热疗温度42~44℃,45min/次,2次/周;同步化疗为S-1或卡培他滨第1-14天,3周方案。观察患者症状缓解情况、不良反应、客观缓解(完全缓解+部分缓解)率、生存情况。结果入组患者年龄56~83岁(中位数71岁),男∶女为7∶1。治疗结束后38例(95%)症状缓解,最常见不良反应为1、2级胃肠道反应及白细胞减低,客观缓解率为88%,2年无进展生存、总生存率分别为69%、71%。结论初步说明微波热疗联合放化疗治疗进展期胃癌可获得较好近期疗效,不良反应可耐受。Objective To preliminarily observe the clinical efficacy of microwave hyperthermia combined with intensity-modulated radiotherapy(IMRT)and chemotherapy for patients with locally advanced gastric cancer.Methods Forty patients who could not been operated or refused operation were enrolled in this clinical trial,who were confirmed as locally advanced proximal or distal gastric cancer by gastroscopy pathology and imaging.Radiotherapy was delivered by IMRT technology for 5 times per week with a total dose of 46 to 56Gy(median dose of 50Gy)in 25 to 28 fractions.Synchronous hyperthermia was given at 42 to 44℃twice a week,45 min/time.S-1 or capecitabine-based synchronous chemotherapy was performed,d1-14/3 weeks.The symptom remission rate,adverse reactions,objective remission rate(complete and partial remission)and survival were observed.Results A total of 40 patients,aged between 56 and 83 years(median age of 71 years),were enrolled in this study.The male-to-female ratio was 7:1.Among them,38 cases(95%)showed symptom remission.The most common adverse reactions were grade 1-2 gastrointestinal reactions and leukopenia.The objective remission rate was 87.5%,the 2-year progression-free survival and overall survival rates were 68.6%and 70.5%,respectively.Conclusion Preliminary findings demonstrate that microwave hyperthermia combined with chemoradiotherapy achieve satisfactory outcomes and yield tolerable toxicity in patients with locally advanced gastric cancer.

关 键 词：胃肿瘤/热疗法 胃肿瘤/放化疗法 治疗结果 

分 类 号：R735.2[医药卫生—肿瘤]