N-Fmoc-2-(正癸胺基)乙醛的波谱数据和结构确证  

Spectral Analysis and Structural Identification of N-Fmoc-2-(n-decylamino)acetaldehyde

作　　者：何益民 马娟[2] 赵文婷 吕永辉 蒙利民 吴孔涛 高浩凌 HE Yi-ming;MA Juan;ZHAO Wen-ting;Lü Yong-hui;MENG Li-min;WU Kong-tao;GAO Hao-ling(Zhejiang Novus Pharmaceuticals Co.,Ltd.,Shaoxing 312300,China;Research&Development Center,Zhejiang Medicine Co.,Ltd.,Shaoxing 312500,China;Zhejiang Medicine Co.,Ltd.,Shaoxing 312300,China;Changhai Biological Compamy,Zhejiang Medicine Co.,Ltd.,Shaoxing 312300,China)

机构地区：[1]浙江创新生物有限公司,浙江绍兴312300 [2]浙江医药股份有限公司研究院,浙江绍兴312500 [3]浙江医药股份有限公司,浙江绍兴312300 [4]浙江医药股份有限公司昌海生物分公司,浙江绍兴312300

出　　处：《精细化工中间体》2021年第1期64-67,72,共5页Fine Chemical Intermediates

摘　　要：N-Fmoc-2-(正癸胺基)乙醛是合成特拉万星的侧链,通过紫外吸收光谱(UV)、红外吸收光谱(IR)、高分辨质谱(HRMS)、核磁共振波谱(^(1)H NMR、^(13)C NMR、DEPT135、^(1)H COSY、HMQC、HMBC)对其进行了结构表征,并对其核磁共振波谱进行了详细的解析和归属。综合运用多种谱学方法确证了其的结构,为其质量研究提供参考。N-Fmoc-2-(n-decylamino)acetaldehyde is the side chain of Telavacin.In this paper,ultraviolet absorption spectrum(UV),infrared absorption spectrum(IR),high resolution mass spectrometry(HRMS),and nuclear magnetic resonance(NMR)spectroscopy(^(1)H NMR,^(13)C NMR,DEPT135,^(1)H COSY,HMQC,HMBC)data were used in characterizing the structure of N-Fmoc-2-(n-decylamino)acetaldehyde,and the nuclear magnetic resonance spectrum was analyzed in detail.A variety of spectroscopy methods were used to confirm the structure of N-Fmoc-2-(n-decylamino)acetaldehyde and provide a reference for its quality research.

关 键 词：特拉万星 波谱表征 结构确证 酰胺键 

分 类 号：TQ460.6[化学工程—制药化工]