A cytoprotective graphene oxide-polyelectrolytes nanoshell for single-cell encapsulation  

作　　者：Luanying He Yulin Chang Junhao Zhu Ying Bi Wenlin An Yiyang Dong Jia-Hui Liu Shihui Wang 

机构地区：[1]College of Life Science and Technology,Beijing University of Chemical Technology,Beijing 100029,China [2]Beijing National Laboratory for Molecular Sciences,College of Chemistry and Molecular Engineering,Peking University,Beijing 100871,China

出　　处：《Frontiers of Chemical Science and Engineering》2021年第2期410-420,共11页化学科学与工程前沿（英文版）

基　　金：This work is supported by the National Key Research and Development Project of China(Grant No.218YFA0903000);the National Natural Science Foundation of China(Grant Nos.21606013,21301015);National Mega-project for Innovative Drugs(Grant No.2019ZX09721001-007-002);Shenzhen Science and Technology Project(Grant No.JCYJ20180507183842516).

摘　　要：Graphene oxide(GO)has been increasingly utilized in the fields of food,biomedicine,environment and other fields because of its benign biocompatible.We encapsulated two kinds of GO with different sizes on yeast cells with the assistance of polyelectrolytes poly(styrene sulfonic acid)sodium salt(PSS)and polyglutamic acid(PGA)(termed as Y@GO).The result does not show a significant difference between the properties of the two types of Y@GO(namely Y@GO1 and Y@GO2).The encapsulation layers are optimized as Yeast/PGA/PSS/PGA/GO/PGA/PSS based on the morphology,dispersity,colony-forming unit,and zeta potential.The encapsulation of GO increases the roughness of the yeast.It is proved that the Y@GO increases the survival time and enhance the activity of yeast cells.The GO shell improves the resistance of yeast cells against pH and salt stresses and extends the storage time of yeast cells.

关 键 词：GO YEAST POLYELECTROLYTE CYTOPROTECTION nanomaterials 

分 类 号：O61[理学—无机化学]