重组人干扰素α-2b阴道泡腾胶囊联合乳酸菌阴道胶囊治疗宫颈HPV感染的疗效  

Efficacy of Recombinant Human Interferon Alpha-2b Vaginal Effervescent Capsule Combined with Lactobacillus Vaginal Capsule in the Treatment of Cervical HPV Infection

作　　者：王秀娟[1] WANG Xiujuan(Beijing Aerospace General Hospital, Beijing 100076, China)

机构地区：[1]北京航天总医院妇产科,北京100076

出　　处：《河北医学》2021年第4期678-682,共5页Hebei Medicine

基　　金：2018年度北京市自然科学基金资助项目,(编号:7182097)。

摘　　要：目的:观察重组人干扰素α-2b阴道泡腾胶囊联合乳酸菌阴道胶囊治疗宫颈HPV感染的疗效以及对阴道微生态改善情况。方法:研究对象选择了2016年5月至2018年5月在我院进行宫颈高危型HPV感染治疗的患者,共140例,采取简单随机分组方法,分为对照组70例和治疗组70例。对照组患者给予重组人干扰素α-2b阴道泡腾胶囊,1粒/次,1粒/d,一个疗程为10d,共进行3个疗程的治疗。而对于治疗组,采取对照组治疗的基础上服用乳酸菌阴道胶囊,1次/晚,以连续用药7d为1个疗程,治疗4个疗程;进行1个月的治疗后对治疗的效果进行相应的评定。评定的方法主要是对于患者的阴道微生物进行复查,同时对患者的查宫颈HPV转阴情况进行复查,复查免疫炎症因子表达。结果:治疗组治疗后转阴44例,有效19例,有效率90%,而对照组则转阴34例,有效17例,两组差异明显(P<0.05)。进行1个月的治疗后,对于治疗组来说,其有64例患者阴道微生物恢复了正常,恢复正常率为91.4%,而对照组正常恢复43例,恢复正常率为61.4%。比较两组患者的阴道分泌物的pH值,其中治疗组为4.1±0.6,而对照组为4.6±0.7,治疗组恢复阴道正常pH值。对两组患者进行Nugent评分,治疗组为(2.2±0.4)分,低于对照组的(2.9±0.8)分,两组之间差异具有统计学意义(P<0.05)。在对两组患者进行1个月的治疗后,IL-4均出现了明显的降低,而IL-12和IFN-γ则都出现了一个显著的上升,与对照组相比,治疗组的幅度明显更大(P<0.05)。结论:重组人干扰素α-2b阴道泡腾胶囊联合乳酸菌阴道胶囊治疗宫颈HPV感染的疗效确切,可以改善阴道微生态。Objective:To observe the efficacy of recombinant human interferon alpha-2b vaginal effervescent capsule combined with Lactobacillus vaginal capsule in the treatment of cervical HPV infection and the improvement of vaginal microecology.Methods:The subjects were selected from May 2016 to May 2018 in our hospital for the treatment of cervical high-risk HPV infection,including 140 cases.According to the different treatments,they were randomly divided into control group(70 cases)and treatment group(70 cases).Patients in the control group were given recombinant human interferon alpha-2b vaginal effervescent capsules,one capsule per day for a course of 10 days within a total of three courses of treatment.For the treatment group,Lactobacillus vaginal capsules were taken on the basis of the treatment of the control group,once a night for a course of 7 days within four courses of treatment;after one month of treatment,the effect of treatment was evaluated accordingly.The main method of evaluation is to reexamine the vaginal microorganisms of patients,at the same time to reexamine the cervical HPV negative transformation of patients,and to reexamine the expression of immunoinflammatory factors.Results:After treatment,44 cases in the treatment group turned negative,and the effective rate was 90%(19 cases),while 34 cases in the control group turned negative,17 cases effective;the difference between the two groups was significant(P<0.05).After treatment of a month,for the treatment group,64 cases of vaginal microbes returned to normal,with a return to normal rate of 91.4%,while 43 cases in the control group returned to normal,with a return to normal rate of 61.4%.The pH value of vaginal secretion in the treatment group was 4.1±0.6)and that in the control group was 4.6±0.7).The normal vaginal PH value was restored in the treatment group.Nugent score of the two groups was(2.2±0.4)in the treatment group,which was lower than(2.9+0.8)in the control group.There was a significant difference between the two groups(P<0.05).After one

关 键 词：宫颈HPV感染 重组人干扰素Α-2B阴道泡腾胶囊 乳酸菌阴道胶囊 阴道微生态 

分 类 号：R73[医药卫生—肿瘤]