内镜黏膜下剥离术对胃肠道间质瘤患者机体氧化应激反应及胃肠功能的影响  

Effects of endoscopic submucosal dissection on oxidative stress of body and gastrointestinal function in patients with gastrointestinal stromal tumor

作　　者：余涛[1] YU Tao(Hanzhong People's Hospital,Hanzhong 723000,China)

机构地区：[1]汉中市人民医院,陕西汉中723000

出　　处：《临床医学研究与实践》2021年第12期41-43,共3页Clinical Research and Practice

摘　　要：目的探究内镜黏膜下剥离术(ESD)对胃肠道间质瘤(GIST)患者氧化应激反应和胃肠功能的影响。方法采用随机数字表法将82例GIST患者分为对照组和研究组,各41例。对照组采用腹腔镜手术治疗,研究组采用ESD进行治疗。比较两组的手术相关指标、复发情况、术后并发症情况、应激反应指标及胃肠功能指标。结果研究组的手术时间、饮食恢复时间及住院时间短于对照组,术中出血量少于对照组,住院费用低于对照组(P<0.01)。两组术后1年疾病复发率及并发症总发生率无显著差异(P>0.05)。术后24 h,研究组的T-AOC水平高于对照组,MDA水平低于对照组(P<0.01)。术后3 d,研究组的GAS水平高于对照组,VIP水平低于对照组(P<0.01)。结论EDS治疗GIST具有创伤小、术中出血量少、术后胃肠功能恢复快、安全性良好的优势,可能与其对胃肠功能和机体氧化应激损伤小有关。Objective To investigate the effects of endoscopic submucosal dissection(ESD)on oxidative stress and gastrointestinal function in patients with gastrointestinal stromal tumor(GIST).Methods Eighty-two patients with GIST were divided into control group and study group by random number table method,with 41 cases in each group.The control group was treated with laparoscopic surgery,and the study group was treated with ESD.The operation related indexes,recurrence,postoperative complications,stress response indexes and gastrointestinal function indexes were compared between the two groups.Results The operation time,diet recovery time and hospitalization time of the study group were shorter than those of the control group,the intraoperative blood loss volume was less than that of the control group,and the hospitalization cost was lower than that of the control group(P<0.01).There were no significant differences in recurrence rate at 1-year after surgery and total incidence of complications between the two groups(P>0.05).At 24 h after operation,the level of T-AOC in the study group was higher than that in the control group,and the level of MDA was lower than that in the control group(P<0.01).At 3 d after operation,the level of GAS in the study group was higher than that in the control group,and the level of VIP was lower than that in the control group(P<0.01).Conclusion EDS in the treatment of GIST has the advantages of less trauma and intraoperative blood loss volume,quick recovery of gastrointestinal function and good safety,which may be related to its less damage to gastrointestinal function and oxidative stress.

关 键 词：胃肠间质瘤 内镜黏膜下剥离术 氧化应激 胃肠功能 

分 类 号：R735[医药卫生—肿瘤]