非酒精性脂肪性肝病患者磁共振质子密度脂肪分数变化  

Implication of magnetic resonanceimaging-proton density fat fraction in patients with nonalcoholic fatty liver diseases

作　　者：贾群玲[1] 徐志宾[1] 韩舒[1] Jia Qunling;Xu Zhibin;Han Shu(Department of Radiology,New District Hospital Affiliated to First Hospital,Henan University of Science and Technology,Luoyang 471023,Henan Province,China)

机构地区：[1]河南科技大学第一附属医院新区医院影像中心,河南省洛阳市471023

出　　处：《实用肝脏病杂志》2021年第3期359-362,共4页Journal of Practical Hepatology

基　　金：河南省医学科技攻关计划项目(编号:201504032)。

摘　　要：目的分析非酒精性脂肪性肝病(NAFLD)患者MRI检查质子密度脂肪分数(MRI-PDFF)变化。方法2018年1月~2020年9月我院诊治的NAFLD患者64例,均接受超声、肝活检和MRI检查,测量PDFF。结果在64例NAFLD患者中,超声诊断轻、中和重度NAFLD患者分别为20例、28例和16例;重度患者体质指数(BMI)、血脂、空腹血糖和MRI-PDFF水平显著高于轻度和中度患者(P<0.05);肝组织学诊断无脂肪变(S0)8例、S122例、S225例和S39例,其MRI-PDFF分别为(3.2±1.4)%、(8.7±6.3)%、(15.4±5.0)%和(22.8±7.4)%,差异显著(P<0.05);诊断肝组织炎症G1、G2和G3级分别为14例、36例和14例,其MRI-PDFF分别为(8.6±7.5)%、(10.9±9.8)%和(14.6±11.3)%,差异显著(P<0.05);诊断肝纤维化F0期18例、F1期24例、F2期14例、F3期6例和F4期2例,其MRI-PDFF分别为(4.6±3.2)%、(9.4±8.1)%、(10.6±7.4)%、(11.3±10.6)%和(7.1±3.4)%,差异显著(P<0.05)。结论不同肝脂肪变程度NAFLD患者MRI-PDFF值具有显著性差异,应用MRI-PDFF检测可能具有量化评价NAFLD患者肝脂肪变程度的临床意义,值得进一步研究。Objective The paper aimed to analyze the clinical implication of magnetic resonance imaging-proton density fat fraction(MRI-PDFF)in patients with nonalcoholic fatty liver diseases(NAFLD).Methods 64 patients with NAFLD were enrolled in our hospital between January 2018 and September 2020,and all underwent sonography,liver biopsies and MRI scan.The MRI-PDFF was obtained.Results Out of the 64 patients with NAFLD,the sonography showed mild,moderate and severe fatty liver in 20 cases,28 cases and 16 cases,and the body mass index,blood fats,fasting blood glucose levels and MRI-PDFF in patients with severe fatty liver were all significantly higher than those in patients with mild or moderate fatty liver(P<0.05);the liver histopathological examination demonstrated no liver tissue steatosis(S0),S1,S2 and S3 in 8 cases,22 cases,25 cases and 9 cases,with the MRI-PDFF of(3.2±1.4)%,(8.7±6.3)%,(15.4±5.0)%and(22.8±7.4)%,respectively,significantly different among them(P<0.05),the liver active inflammation grading(G)1,G2 and G3 were in 14 cases,36 cases and 14 cases,with the MRI-PDFF of(8.6±7.5)%,(10.9±9.8)%and(14.6±11.3)%,significantly different among them(P<0.05),and the liver fibrosis(F)0 in 18 cases,F1 in 24 cases,F2 in 14 cases,F3 in 6 cases and F4 in 2 cases,with the MRI-PDFF of being(4.6±3.2)%,(9.4±8.1)%,(10.6±7.4)%,(11.3±10.6)%and(7.1±3.4)%,significantly different among them(P<0.05).Conclusion The MRI-PDFF changes and significantly different in patients with different degree of fatty liver,which might help the early diagnosis of patients with hepatic steatosis easily.

关 键 词：非酒精性脂肪性肝病 磁共振质子密度脂肪分数 肝脂肪变 诊断 

分 类 号：R575.5[医药卫生—消化系统]