液体发酵生产灵芝三萜酸的过程调控研究进展  

Advances on process regulation of Ganoderma triterpene acids production by liquid fermentation

作　　者：李丽[1,2] 杨云丽 杨小凡 何伟 袁恺 朱威宇 彭超 何一凡 董银卯[1,2] 周卫强 LI Li;YANG Yunli;YANG Xiaofan;HE Wei;YUAN Kai;ZHU Weiyu;PENG Chao;HE Yifan;DONG Yinmao;ZHOU Weiqiang(College of chemistry and materials engineering of Beijing Technolgoy&Business University,Beijing 100048,China;Beijing Key Lab of Plant Resource Research and Development,Beijing 100048,China;Nutrition&Health Research Institute,COFCO Corporation,Beijing 102209,China)

机构地区：[1]北京工商大学化学与材料工程学院,北京100048 [2]北京市植物资源研究开发重点实验室,北京100048 [3]中粮营养健康研究院有限公司,北京102209

出　　处：《食品与发酵工业》2021年第8期304-312,共9页Food and Fermentation Industries

基　　金：中国轻工业化妆品重点实验室开放课题项目(KLC-2020-YB3)。

摘　　要：灵芝三萜酸是灵芝发挥免疫调节功能的特征性成分之一。目前三萜酸的来源包括子实体提取、灵芝孢子粉破壁提取、液体发酵等,其中液体发酵工艺因具有周期短、发酵条件易精确控制,并可实现工业化生产等优点,成为国内外研究的热点。该文从过程发酵条件和外源诱导子2个方面对三萜酸液体发酵调控进行综述,为提高三萜酸产量提供发酵技术参考,并对相关研究工作进行展望。Ganoderma triterpene acids(GTAs)are one of the main characteristic components of Ganoderma lucidum to exert its immunoregulatory function.The production methods of GTAs include fruit body extraction,sporoderm-broken spores and liquid submerged fermentation.The liquid fermentation of G.lucidum is viewed as a research hotspot globally due to its advantages,including short cycle,easy and precise control of fermentation conditions and feasible industrial production.In this paper,the regulation of GTAs liquid submerged fermentation is reviewed in two aspects,fermentation conditions and exogenous elicitors,which can provide a reference for fermentation technology to increase the production of GTAs,and prospect for related research.

关 键 词：灵芝三萜酸 液体发酵 代谢调控 诱导物质 

分 类 号：TQ921[轻工技术与工程—发酵工程]