CRG/PVA复合水凝胶的3D打印工艺研究  

3D printing process of CRG/PVA composite hydrogel

作　　者：伍硕中 汤晓燕[2] 云忠[2] 陈轲 WU Shuozhong;TANG Xiaoyan;YUN Zhong;CHEN Ke(Light Alloy Research Institute,Central South University,Changsha 410083,China;School of Mechanical and Electrical Engineering,Central South University,Changsha 410083,China)

机构地区：[1]中南大学轻合金研究院,湖南长沙410083 [2]中南大学机电工程学院,湖南长沙410083

出　　处：《中国医学物理学杂志》2021年第4期495-500,共6页Chinese Journal of Medical Physics

基　　金：国家自然科学基金(31670999);湖南省自然科学基金(2019JJ40364)。

摘　　要：利用生物高分子材料聚乙烯醇(PVA)、卡拉胶(CRG)的物理、生物学性能及其特殊的交联特性,制备一种可用于3D打印的CRG/PVA复合水凝胶生物墨水材料,为后期的工艺研究提供材料基础。构建了一套适合CRG/PVA复合水凝胶挤出打印的3D打印系统,并在此基础上研究和分析了活塞挤出速度、喷头移动速度、打印高度、线间距等工艺参数对水凝胶尺寸精度的影响。当挤出速度为0.3~0.6 mm/s、喷头移动速度为15~20 mm/s、打印高度为0.3~0.6 mm、线间距大于1.4 mm时,CRG/PVA复合水凝胶有很好的打印效果。水凝胶的临界坍塌角度实验显示对三维打印结构设计支撑结构能增大水凝胶的临界坍塌角度,使得大倾斜角度结构能够成功打印。Based on the physical,biological and specific cross-linking characteristics of biopolymer materials polyvinyl alcohol(PVA)and carrageenan(CRG),a CRG/PVA composite hydrogel bio-ink material that can be used for 3D printing is prepared,thereby providing material for the process study.A set of 3D printing system suitable for CRG/PVA composite hydrogel extrusion printing is constructed,and on this basis,the effects of process parameters such as piston extrusion speed,nozzle moving speed,printing height,line spacing,etc.on the dimensional accuracy of the hydrogel are studied and analyzed.With the extrusion speed of 0.3-0.6 mm/s,the nozzle moving speed of 15-20 mm/s,the printing height of 0.3-0.6 mm,and the line spacing greater than 1.4 mm,the 3D printing resultof CRG/PVA composite hydrogel is the optimal.The experiment on the critical collapse angle of the hydrogel showed that the support structure designed for 3D printing canincrease the critical collapse angle of the hydrogel,so that the large tilt angle structure alsocan be successfully printed.

关 键 词：聚乙烯醇 卡拉胶 3D打印 临界坍塌角度 

分 类 号：R318[医药卫生—生物医学工程]