52种药食两用傣族药急性经口毒性评价  

Evaluation of Acute Oral Toxicity of 52 Kinds of Edible Dai Medicine

作　　者：李宜航[1,2] 李光 俞静[1,2] 李学兰 唐德英 苏晶[1,2] 牟燕 LI Yi-hang;LI Guang;YU Jing;LI Xue-lan;TANG De-ying;SU Jing;MOU Yan(Yunnan Branch,Institute of Medicinal Plant Development,Chinese Academy of Medical Sciences,Jinghong 666100,China;Key Laboratory of Dai and Southern Medicine of Xishuangbanna Dai Autonomous Prefecture,Jinghong 666100,China)

机构地区：[1]中国医学科学院药用植物研究所云南分所,云南景洪666100 [2]西双版纳州傣药南药重点实验室,云南景洪666100

出　　处：《中国现代中药》2021年第3期485-490,共6页Modern Chinese Medicine

基　　金：州级财政傣药南药产业发展基金项目(西政生物办发〔2018〕5号);云南省工信委中药饮片产业发展专项(2019-YZ-065);中国医学科学院创新工程项目(2016-I2M-1-012);云南省技术创新人才培养项目(2017HB097)。

摘　　要：目的:初步考察52种药食两用傣族药的急性毒性。方法:将52种药食两用傣族药参考惯用烹饪方式分别处理后,采用限量法和寇氏法开展小鼠急性经口毒性评价实验。结果:45种傣族药经过限量法实验,在较大剂量下未引起小鼠死亡,未见明显毒性。7种傣族药可测出半数致死量,均属于无毒级别。结论:多数药食两用傣族药不具备明显毒性,安全性较好,但仍建议进一步开展亚急性毒性或长期毒性实验研究以保障食品安全。Objective:A preliminary investigation was made on the acute toxicity of 52 edible Dai medicine.Methods:After treating 52 kinds of edible Dai medicine with reference to conventional cooking methods,mice were used as experimental animals to carry out acute oral toxicity evaluation experiments using the limit test and the Korbor method.Results:It was observed in limited test that 45 kinds of Dai medicine did not cause animal death at larger doses and did not show significant toxicity.Median lethal dose of 7 kinds of Dai medicine was determined,all of which belonged to the non-toxic level.Conclusion:Most edible Dai medicine do not have obvious toxicity,but it is still recommended to carry out further subacute toxicity or long-term toxicity experimental research to ensure food safety.

关 键 词：急性毒性 药食两用 傣族药 限量法 寇氏法 

分 类 号：R285.5[医药卫生—中药学]