一氧化氮供体型心脑血管药物研究的实践与思考  

Research and reflections on the nitric oxide-donating cardio-cerebrovascu⁃lar drugs

作　　者：吴建兵 黄张建[1] 张奕华[1] WU Jianbing;HUANG Zhangjian;ZHANG Yihua(Center of Drug Discovery,China Pharmaceutical University,Nanjing 210009,China)

机构地区：[1]中国药科大学新药研究中心,南京210009

出　　处：《中国药科大学学报》2021年第2期129-143,共15页Journal of China Pharmaceutical University

基　　金：国家自然科学基金资助项目(No.81773573,No.81822041,No.81673305,No.81273378,No.81202408,No.39770869,No.30973608,No.30472085,No.30271491,No.21372261);“重大新药创制”科技重大专项资助项目(No.2009ZX09103-095,No.2009ZX09103-090)。

摘　　要：一氧化氮(nitric oxide,NO)作为信使物质和/或效应分子在心血管、神经、免疫等系统中发挥着极其重要的作用。NO生成不足或信号传导异常与多种疾病的形成和发展密切相关,直接或间接调控体内NO水平及其相关代谢途径的研究已成为生物医学和药学领域研究的热点。本文介绍了体内NO的产生及其在心脑血管中的生理、病理作用,综述了本课题组在NO供体型心脑血管药物及相关药物研究方面所开展的工作,并对今后NO供体型心脑血管药物研究发展方向进行了展望。Nitric oxide(NO)as a signal transduction species and/or effector molecule plays an extremely impor⁃tant role in the cardiovascular,nervous,and immune systems.Insufficient production or abnormal signal trans⁃duction of NO is closely associated with onset and progression of many diseases.Studies on direct or indirect regulation of NO levels in vivo and related metabolic pathways have become a hot spot in biomedical and pharma⁃ceutical fields.This review briefly introduces the generation of NO in vivo and its physiological and pathological functions in cardio-cerebrovascular system,with focus on the authors'research on NO-donating cardio-cerebro⁃vascular and related drugs,aiming to provide some reference for future development of these drugs.

关 键 词：一氧化氮(NO) NO供体型心脑血管药物 生理/病理作用 效应分子 信使物质 

分 类 号：R914[医药卫生—药物化学]