Drug-induced gingival overgrowth in cardiovascular patients  

作　　者：Lucija Bajkovec Anna Mrzljak Robert Likic Ivan Alajbeg 

机构地区：[1]Institute of Emergency Medicine of Medimurje County,Institute of Emergency Medicine of Međimurje County,Cakovec 40000,Croatia [2]Department of Gastroenterology and Hepatology,University Hospital Center Zagreb,Zagreb 10000,Croatia [3]School of Medicine,University of Zagreb,Zagreb 10000,Croatia [4]Unit for Clinical Pharmacology and TherapeuticsDepartment of Internal Medicine,University Hospital Centre Zagreb,Zagreb 10000,Croatia [5]Department of Oral Medicine,University of Zagreb School of Dental Medicine and University Hospital Centre Zagreb,Zagreb 10000,Croatia

出　　处：《World Journal of Cardiology》2021年第4期68-75,共8页世界心脏病学杂志（英文版）（电子版）

摘　　要：Drug-induced gingival overgrowth(DIGO)is a pathological growth of gingival tissue,primarily associated with calcium channel blockers and immunosuppressants.Consequently,it is mainly seen in cardiovascular and transplanted patients.Nifedipine remains the main calcium channel blocker related to the development of this unpleasant side-effect.As for immunosuppress-ants,cyclosporin is the leading causative agent,whereas other drugs from this druggroup,including tacrolimus,have better safety profiles.Accumulated collagen with inflammatory infiltrates is the histological hallmark of this condition.Several factors are involved in the pathogenesis and can increase the risk,such as male gender,younger age,pre-existing periodontal inflammation,and concomitant use of other DIGO-inducing medications.Patients with DIGO may experience severe discomfort,trouble with speech and mastication,pain,and teeth loss,aside from cosmetic implications.Furthermore,these patients also have an increased risk for cardiovascular diseases.The interdisciplinary approach and cooperation with dental care experts are necessary for patient management.Treatment includes discontinuing the drug and switching to one with a better profile,improving oral hygiene,and surgical removal of enlarged tissue.Recognizing the potential of commonly used medications to cause DIGO and its effect on patients'health is necessary for early detection and adequate management of this complication.

关 键 词：Drug-induced gingival overgrowth Calcium channel blocker NIFEDIPINE 

分 类 号：R969.3[医药卫生—药理学]