This work was supported by grants from the Ministry of Science and Technology of China (2021YFA0804803);the National Natural Science Foundation of China (81870189,82070266,81900243,81930012,81730013,92168120 and 81974506);the Beijing Natural Science Foundation(Z200019).
It is of great clinical significance to develop potential novel strategies to prevent diabetic cardiovascular complications.Endothelial progenitor cell(EPC)dysfunction is a key contributor to diabetic vascular complic...
Objective: to explore and analyze the effect of valsartan and nifedipine in community hypertension patients. Methods: the research object was 64 patients with hypertension who received treatment in community health ce...
by the Nanjing Clinical Research Center for Oral Diseases,No.2019060009;the Nanjing Medical Science and Technology Development Program,No.YKK17139;the Medical Innovation Team of Scientific and Educational Health in the Jiangsu Province,No.CXTDB2017014.
BACKGROUND We report three patients with drug-induced gingiva overgrowth(DIGO)caused by nifedipine,a calcium channel blocker,who were treated and followed up for 1–3 years.We discussed their symptoms,treatment proces...
supported by Heilongjiang Natural Science Foundation(No.LH2019H107);Innovation Fund for postgraduates of Heilongjiang University of Chinese Medicine(No.2020yjscx058)。
Objective:To explore the mechanism underlying the effect of Panax notoginseng saponins(PNS)on the pharmacokinetics of nifedipine(NF)in rats.Materials and Methods:Twenty-four rats were randomly divided into blank(BL)gr...
Objective: to analyze the clinical efficacy of magnesium sulfate and nifedipine in the treatment of pregnancy induced hypertension syndrome. Methods: 80 patients with PIH admitted from June 2018 to August 2020 were ra...
Objective: to observe the therapeutic effect of nifedipine and magnesium sulfate combined with labetalol in the clinical treatment of pregnant women with pregnancy induced hypertension. Methods: the time of this study...
Drug-induced gingival overgrowth(DIGO)is a pathological growth of gingival tissue,primarily associated with calcium channel blockers and immunosuppressants.Consequently,it is mainly seen in cardiovascular and transpla...
supported by grants from the National Natural Science Foundation of China(81625005 to Z.P.F.);the Program for“Hundred-Thousand-Ten thousand”Talents in Beijing(2018A16 to Z.P.F.)。
Drug-induced gingival overgrowth(DIGO) is recognized as a side effect of nifedipine(NIF);however, the underlying molecular mechanisms remain unknown. In this study, we found that overexpressed mi R-4651 inhibits cell ...
Herein,the purpose of this study is to evaluate the effects of kaempferol on bioavailability and pharmacokinetics of nifedipine and its metabolite dehydronifedipine in rats.The experimental design is based on with or ...