Clinical presentation and management of drug-induced gingival overgrowth: A case series  

作　　者：Li Fang Bao-Chun Tan 

机构地区：[1]Department of Stomatology,The Affiliated Suqian First People's Hospital of Nanjing Medical University,Suqian 223800,Jiangsu Province,China [2]Departments of Periodontology,Nanjing Stomatological Hospital,Medical School of Nanjing University,Nanjing 210008,Jiangsu Province,China

出　　处：《World Journal of Clinical Cases》2021年第32期9926-9934,共9页世界临床病例杂志

基　　金：by the Nanjing Clinical Research Center for Oral Diseases,No.2019060009;the Nanjing Medical Science and Technology Development Program,No.YKK17139;the Medical Innovation Team of Scientific and Educational Health in the Jiangsu Province,No.CXTDB2017014.

摘　　要：BACKGROUND We report three patients with drug-induced gingiva overgrowth(DIGO)caused by nifedipine,a calcium channel blocker,who were treated and followed up for 1–3 years.We discussed their symptoms,treatment process,treatment prognosis,and follow-up results.CASE SUMMARY All the patients had a history of nifedipine treatment to control hypertension.Besides nifedipine,Patient 1 was prescribed immunosuppressant cyclosporine A to control nephritis,which is also implicated in GO.Thus,we assumed that a synergistic effect between the drugs contributed to the severity of Patient 1’s condition.This condition has been reported to be more pronounced in patients with periodontitis.In the course of treatment,Patients 1 and 2 did not stop or change drugs.After initial periodontal treatment,periodontal surgery,and later periodontal support and better plaque control,their gingival hyperplasia was well managed and controlled.Under the guidance of a physician,Patient 3 replaced her calcium-channel blocker drug with losartan potassium and hydrochlorothiazide tablets.She received initial treatment without surgery,obtaining a good curative effect.CONCLUSION Patients’compliance,self-plaque control,and professional periodontal therapy have a vital role in treating and preventing the recurrence of DIGO.

关 键 词：Drug-induced gingiva overgrowth NIFEDIPINE Periodontal surgery Treatment prognosis Case report 

分 类 号：R781[医药卫生—口腔医学]