胃癌患者血清miR-515-3p水平与临床病理特征及预后的关系  

Relationship between serum miR-515-3p level and clinicopathological characteristics and prognosis in patients with gastric cancer

作　　者：吴维宇[1] 汪力[2] 张雪莲[1] 黎军 WU Weiyu;WANG Li;ZHANG Xuelian;LI Jun(Department of Gastroenterology,he First Affiliated Hospital of Chengdu Medical College,Chengdu 610500,China;Health Checkup Center,the First Affiliated Hospital of Chengdu Medical College,Chengdu 610500,China)

机构地区：[1]成都医学院第一附属医院消化内科,610500 [2]成都医学院第一附属医院健康体检中心,610500

出　　处：《国际消化病杂志》2021年第2期113-117,共5页International Journal of Digestive Diseases

基　　金：四川省卫生计生委科研课题(17PJ013)。

摘　　要：目的探讨胃癌患者血清miR-515-3p水平与临床病理特征及预后的关系。方法选择2013年1月至2015年1月在成都医学院第一附属医院接受胃癌手术治疗的130例原发性胃癌患者作为原发性胃癌组,另选择同期在该院进行体检的100名健康志愿者作为正常对照组。分析两组的血清miR-515-3p水平差异,以及原发性胃癌患者血清miR-515-3p水平与临床病理特征的关系。采用受试者工作特征(ROC)曲线分析血清miR-515-3p水平对原发性胃癌患者预后的预测价值,采用Kaplan-Meier生存曲线分析不同血清miR-515-3p水平的原发性胃癌患者的预后差异,采用Cox比例风险模型分析胃癌患者预后的影响因素。结果原发性胃癌组的血清miR-515-3p水平高于正常对照组(P<0.05)。不同性别、年龄、肿瘤最大直径、Lauren′s分型的原发性胃癌患者的血清miR-515-3p水平差异无统计学意义(P>0.05)。不同TNM分期、分化程度、局部浸润深度、淋巴结转移的原发性胃癌患者的血清miR-515-3p水平差异有统计学意义(P<0.05)。经ROC曲线发现,血清miR-515-3p水平预测原发性胃癌患者随访期内死亡的最佳截断值为0.67,ROC曲线下面积(AUC)为0.790(95%CI0.714~0.865),对应的敏感度、特异度分别为71.62%、64.29%。Kaplan-Meier生存曲线分析显示,低miR-515-3p组的原发性胃癌患者的预后优于高miR-515-3p组(P<0.05)。Cox比例风险模型分析显示,血清miR-515-3p水平较高、TNM分期较高、分化程度较低、局部浸润深度较大及合并淋巴结转移是原发性胃癌患者预后不良的独立危险因素(P<0.05)。结论原发性胃癌患者的血清miR-515-3p水平异常升高,是预后不良的独立危险因素。Objective This paper intends to explore the relationship between serum miR-515-3p level and clinicopathological characteristics and prognosis in patients with gastric cancer.Methods A total of 130 patients with primary gastric cancer who underwent gastric cancer surgery in the First Affiliated Hospital of Chengdu Medical College from January 2013 to January 2015 were selected as the primary gastric cancer group.In addition,100 healthy volunteers who underwent physical examination in this hospital during the same period were selected as the normal control group.The differences in the serum miR-515-3p levels between the two groups and the relationship between the serum miR-515-3p levels and the clinicopathological characteristics in patients with primary gastric cancer were analyzed.The receiver operating characteristic(ROC)curve was used to analyze the predictive value of serum miR-515-3p levels on the prognosis of patients with primary gastric cancer.The Kaplan-Meier survival curve was used to analyze the prognostic differences of primary gastric cancer patients with different serum miR-515-3p levels,and the Cox proportional hazards model was used to analyze the factors affecting the prognosis of gastric cancer patients.Results The level of serum miR-515-3p in the primary gastric cancer group was higher than that in the normal control group(P<0.05).There was no significant difference in the serum miR-515-3p levels in patients with primary gastric cancer of different gender,age,maximum tumor diameter,and Lauren′s type(P>0.05).There were statistically significant differences in the serum miR-515-3p levels in patients with primary gastric cancer with different TNM stages,differentiation degree,local infiltration depth,and lymph node metastasis(P<0.05).According to the ROC curve,the optimal cut-off value of serum miR-515-3p for predicting the death of patients with primary gastric cancer during the follow-up period was 0.67,and the area under the ROC curve(AUC)was 0.790(95%CI:0.714~0.865),The corresponding sensitiv

关 键 词：胃癌 miR-515-3p 临床病理特征 预后 

分 类 号：R73[医药卫生—肿瘤]