头颈动脉粥样硬化的计算流体力学研究进展  

Research progress of computational fluid dynamics for intracranial and carotid atherosclerosis

作　　者：王安聪 童薪宇 徐远清[1] 梅玉倩 陈端端 Wang Ancong;Tong Xinyu;Xu Yuanqing;Mei Yuqian;Chen Duanduan(School of Life Science,Beijing Institute of Technology,Beijing 100081,China)

机构地区：[1]北京理工大学生命学院,100081

出　　处：《中国脑血管病杂志》2021年第4期271-276,共6页Chinese Journal of Cerebrovascular Diseases

基　　金：国家自然科学基金(82001938,81970404,82072009);北京市自然科学基金(Z190014,L192010,L192045)。

摘　　要：颅内动脉粥样硬化和颈动脉粥样硬化是缺血性卒中的主要原因。动脉粥样硬化是一种全身性的炎性反应,其形成原因十分复杂,目前大多数研究认为其形成和发展与血流动力学因素密切相关。计算流体力学可以模拟人体血液流动,得到血流动力学参数,通过进一步与临床、形态学等信息结合,揭示可能影响动脉粥样硬化进展的力学相关因素。该文通过回顾近年来头颈动脉粥样硬化的计算流体力学研究,总结不同研究中提出的相关血流动力学参数,分析局部血流动力学与动脉粥样硬化斑块发生、发展的关系,以期为斑块区域力学特征的分析、斑块易损性的识别提供参考依据,为动脉粥样硬化易损斑块的早期筛查提供解决方案,从而指导其治疗方案。Intracranial and carotid atherosclerosis are main causes of ischemic stroke.The mechanisms for the formation of atherosclerosis,a disease regarded as systematic inflammation response,are very complicated.Recently,most studies believe that the formation and development of atherosclerosis are closely related to hemodynamic metrics.Computational fluid dynamics can simulate the blood flow in the body in order to obtain hemodynamic parameters.Combined with clinical and morphological information,hemodynamic analysis can reveal the mechanical features that may affect atherosclerosis.This article reviewed computational fluid dynamics researches of intracranial and carotid atherosclerosis in recent years and summarized related hemodynamic parameters.Relationship between local hemodynamics and the development of atherosclerotic plaques was analyzed in order to offer reference for plaque local mechanical feature analysis and vulnerable plaques identification.Furthermore,this article may provide solutions for the early detection of atherosclerotic vulnerable plaques and guide the treatment.

关 键 词：缺血性卒中 动脉粥样硬化 血流动力学 计算流体力学 综述 

分 类 号：R743.3[医药卫生—神经病学与精神病学]