健脾止泻汤对结肠癌术后腹泻患者胃肠激素水平和生活质量的影响  

Effect of Jianpi Zhixie Decoction on gastrointestinal hormone and quality of life in patients with diarrhea after surgery for colon cancer

作　　者：吴永梅 邹群 罗酩 张霁雯 李文娟 彭梦莹 WU Yongmei;ZOU Qun;LUO Ming;ZHANG Jiwen;LI Wenjuan;PENG Mengying(Luodian Hospital of Baoshan District, Shanghai 201908, China)

机构地区：[1]上海市宝山区罗店医院,上海201908

出　　处：《现代中西医结合杂志》2021年第12期1291-1295,共5页Modern Journal of Integrated Traditional Chinese and Western Medicine

基　　金：上海市宝山区科学技术委员会科技创新专项资金项目(20-E-26)。

摘　　要：目的观察健脾止泻汤对结肠癌术后腹泻患者胃肠激素水平和生活质量的影响。方法将2018年1月—2019年2月上海市宝山区罗店医院诊治的84例结肠癌术后腹泻患者随机分为2组,对照组给予盐酸洛哌丁胺胶囊治疗,观察组给予健脾止泻汤治疗,均连续治疗4周。对比2组治疗前后主要症状积分(大便性状、大便次数、肠鸣矢气、腹痛、腹胀)、胃肠激素水平[胃动素(MTL)、抑胃肽(GIP)],统计2组生活质量改善情况、临床疗效和不良反应发生情况。结果2组治疗后大便性状、大便次数、肠鸣矢气、腹痛、腹胀积分及MTL水平均明显低于治疗前(P均<0.05),且观察组明显低于对照组(P均<0.05);2组治疗后GIP水平均明显高于治疗前(P均<0.05),且观察组明显高于对照组(P<0.05);观察组治疗后生活质量总有效率为92.9%(39/42),明显高于对照组的71.4%(30/42),差异有统计学意义(P<0.05);观察组治疗总有效率为90.5%(38/42),明显高于对照组的71.4%(30/42),差异有统计学意义(P<0.05);观察组不良反应发生率为4.8%(2/42),明显低于对照组的23.8%(10/42),差异有统计学意义(P<0.05)。结论健脾止泻汤能够显著减轻结肠癌术后腹泻患者症状,调节胃肠激素水平,改善生活质量,且不良反应少。Objective It is to observe the effect of Jianpi Zhixie Decoction on the levels of gastrointestinal hormone and quality of life in patients with diarrhea after surgery for colon cancer.Methods Eighty-four patients with diarrhea after surgery for colon cancer diagnosed and treated in Luodian Hospital of Baoshan District from January 2018 to February 2019 were randomly divided into 2 groups.The control group was treated with loperamide hydrochloride capsules,the observation group was treated with Jianpi Zhixie Decoction,both groups were continuously treated for 4 weeks.The scores of main symptoms(fecal character,stool frequency,borborygmus and flatus,abdominal pain,abdominal distension),the levels of gastrointestinal hormone[motilin(MTL),gastric inhibitory peptide(GIP)]in the two groups were compared before and after treatment,and the improvement of the quality of life of the patients and clinical efficacy were evaluated,the occurrence of adverse reactions was counted.Results The scores of stool character,stool frequency,borborygmus and flatus,abdominal pain,abdominal distension and MTL level after treatment were significantly lower than those before treatment in the two groups(P<0.05),and the observation group was significantly lower than the control group(P<0.05);the level of GIP after treatment was significantly higher than that before treatment in the two groups(both P<0.05),and the observation group was significantly higher than the control group(P<0.05);the total effective rate of quality of life in the observation group after treatment was 92.9%(39/42),which was significantly higher than 71.4%(30/42)in the control group,and the difference was statistically significant(P<0.05);the total effective rate of treatment in the observation group was 90.5%(38/42),which was significantly higher than 71.4%in the control group(30/42),the difference was statistically significant(P<0.05);the incidence of adverse reactions in the observation group was 4.8%(2/42),which was significantly lower than 23.8%(10/42)in the control

关 键 词：结肠癌 术后腹泻 健脾止泻汤 胃肠激素 生活质量 

分 类 号：R735.35[医药卫生—肿瘤]