Metabolic and biological changes in children with obesity and diabetes  

作　　者：Shirou Matsumoto Tomomi Nakamura Fusa Nagamatsu Jun Kido Rieko Sakamoto Kimotoshi Nakamura 

机构地区：[1]Department of Pediatrics,Faculty of Medical Sciences,Kumamoto University,Kumamoto 860-8556,Japan [2]Department of Perinatal Care Unit,Kumamoto University Hospital,Kumamoto University,Kumamoto 860-8556,Japan

出　　处：《World Journal of Meta-Analysis》2021年第2期153-163,共11页世界荟萃分析杂志

摘　　要：The World Health Organization has stated that obesity in childhood is one of themost serious public health challenges of the 21st century. Overweightness andobesity in early childhood lead to a higher risk of overweightness and obesity inadulthood, thus conferring an increased risk of chronic inflammatory conditions,including type 2 diabetes mellitus, cardiovascular diseases, non-alcoholic fattyliver disease, and some cancers. Therefore, metabolome analysis, targeted atscreening and intervening in childhood obesity, is very important. Recent studieshave indicated that amino acid and lipid metabolism could influence metabolicpathways in children with obesity. For this review, we searched clinical dataaddressing metabolomic profiles and insulin resistance (IR) in children withobesity from inception to February 2021 in Medline, Web of Science, and Scopus.According to our search, branched-chain amino acids (BCAAs), aromatic aminoacids, and acylcarnitines have reportedly been associated with IR as biomarkersfor diabetes in children. BCAAs, tyrosine, and phenylalanine could be predictorsof the future development of diabetes in nondiabetic subjects. In addition, it iswell known that insulin regulates BCAA metabolism, and BCAA is a biomarkerfor IR. To interpret the mechanism behind metabolic changes in obesity, it is veryimportant to understand the pathways and combinations related with amino acid,lipid and glucose metabolism. In this review, we summarize studies on metabolicchanges to understand metabolomics in children with obesity.

关 键 词：Children with obesity Diabetes mellitus Insulin resistance Amino acids ACYLCARNITINE Metabolomics 

分 类 号：R58[医药卫生—内分泌]