早期胃癌内镜诊断结果与基质金属蛋白酶-9的相关性研究  

Association between the diagnostic results of digestive endoscopy and matrix metalloproteinase-9 for early gastric cancer

作　　者：陈相波[1] 宋玉琼[2] 许婷婷[1] 何壬松 王育斌[3] CHEN Xiang-bo;SONG Yu-qiong;XU Ting-ting;HE Ren-song;WANG Yu-bin(Endoscope Room,Quanzhou First Hospital Affiliated to Fujian Medical University,Quanzhou 362000,China;Department of Neurology,Quanzhou First Hospital Affiliated to Fujian Medical University,Quanzhou 362000,China;Department of Gastroenterology,Quanzhou First Hospital Affiliated to Fujian Medical University,Quanzhou 362000,China)

机构地区：[1]福建医科大学附属泉州第一医院内窥镜室,泉州362000 [2]福建医科大学附属泉州第一医院神经内科,泉州362000 [3]福建医科大学附属泉州第一医院消化内科,泉州362000

出　　处：《中国肿瘤临床与康复》2021年第3期268-271,共4页Chinese Journal of Clinical Oncology and Rehabilitation

摘　　要：目的探讨早期胃癌的消化内镜诊断结果与基质金属蛋白酶-9(MMP-9)的相关性。方法选取2018年12月至2020年12月间福建医科大学附属泉州第一医院收治的60例早期胃癌患者,均行电子胃镜、染色内镜、放大内镜及超声内镜检查,将诊断结果与腹腔镜手术及内镜黏膜下剥离术(ESD)后病理诊断进行对比。取空腹血清,检测MMP-9水平,对比消化内镜诊断不同程度患者MMP-9水平情况,分析早期胃癌患者消化内镜诊断结果与MMP-9的相关性。结果患者消化内镜诊断与病理诊断虽具有一定差异,但差异无统计学意义(P>0.05)。患者消化内镜诊断分期、淋巴结转移和侵袭程度的MMP-9表达水平比较,差异均有统计学意义(均P<0.05)。消化内镜诊断不同病理分期、淋巴结转移和侵袭程度的患者与MMP-9均呈正相关,差异有统计学意义(均P<0.05),肿瘤直径与MMP-9水平无明显相关性,差异无统计学意义(P>0.05)。结论消化内镜对早期胃癌患者的病理诊断准确性较高,早期胃癌患者的消化内镜病理诊断结果与MMP-9具有一定相关性,临床可采用消化内镜联合MMP-9检测对早期胃癌侵袭深度进行诊断。Objective To investigate the association between the diagnostic results of digestive endoscopy for advanced gastric cancer and the levels of matrix metalloproteinase-9(MMP-9).Methods Sixty patients with early gastric cancer who were admitted to Quanzhou First Hospital Affiliated to Fujian Medical University from December 2018 to December 2020 were selected as the research subjects.All patients were examined using electronic gastroscopy,staining endoscopy,magnifying endoscopy and endoscopic ultrasonography,and the diagnosis results were compared with the pathological diagnostic results after laparoscopic surgery and endoscopic submucosal dissection(ESD).Enzyme-linked immunosorbent assay(ELISA)was used to detect the level of MMP-9 in serum,and the level of MMP-9 in patients of different degrees of diagnostic results of digestive endoscopy was compared.The association between the diagnostic results of digestive endoscopy and the level of MMP-9 was analyzed.Results There was a certain difference between the diagnostic results of digestive endoscopy and pathological diagnosis,but the difference was not statistically significant(P>0.05).There were significant differences in the levels of MMP-9 among patients of different staging and different degree of lymph node metastasis and invasion(all P<0.05).Different staging and different degree of lymph node metastasis and invasion diagnosed by digestive endoscopy were positively associated with the level of MMP-9(all P<0.05).Tumor diameter was not associated with the level of MMP-9(P>0.05).Conclusion The diagnostic accuracy of digestive endoscopy for early gastric cancer was high compared with pathological diagnosis.The diagnostic results were associated with MMP-9 level.Therefore,digestive endoscopy combined with matrix metalloproteinase-9 can be clinically used for the diagnosis of invasion depth of early gastric cancer.

关 键 词：早期胃肿瘤 消化内镜 基质金属蛋白酶-9 

分 类 号：R735.2[医药卫生—肿瘤]