磁共振弥散加权成像在肺癌患者诊断中的应用研究  

Significance of diffusion weighted imaging for the diagnosis of lung cancer

作　　者：韩云鹏[1] 杨立臣[1] 王伟[1] 姜斌[1] HAN Yun-peng;YANG Li-chen;WANG Wei;JIANG Bin(Department of Radiology,Dalian Third People’s Hospital,Dalian 116037,China)

机构地区：[1]大连市第三人民医院放射科,大连116037

出　　处：《中国肿瘤临床与康复》2021年第3期298-301,共4页Chinese Journal of Clinical Oncology and Rehabilitation

摘　　要：目的探讨磁共振弥散加权成像(DWI)在肺癌患者诊断中的应用价值研究。方法选取2016年5月至2019年8月间大连市第三人民医院收治的经病理检查确诊的89例肺癌患者,均行DWI检查,分析DWI在肺癌诊断中的应用价值。结果随着b值升高,肺癌不同病理类型下表面弥散系数(ADC)值呈下降趋势,其中腺癌在不同b值下ADC值高于小细胞肺癌和鳞状细胞癌,组间ADC值比较,差异均有统计学意义(均P<0.05)。随着b值升高,不同分化程度腺癌ADC值水平下降,且高分化腺癌ADC值高于低分化腺癌,差异均有统计学意义(均P<0.05)。b值取0~800s/mm2时,受试者工作曲线下面积最大,灵敏度和特异度最高。结论DWI能提供肺癌细胞结构及细胞膜完整性等功能参数信息,有助于早期发现肺部肿瘤,描述肿瘤特征,在肺癌诊断及鉴别诊断中具有较高的临床应用价值。Objective To investigate the significance of diffusion weighted imaging(DWI)for the diagnosis of lung cancer.Methods From May 2016 to August 2019,89 patients with lung cancer confirmed by pathological examination at Dalian Third People’s Hospital were selected as the research subjects.All patients were examined using DWI,and the results were recorded.The application value of DWI for the diagnosis of lung cancer was analyzed.Results With the increase of b value,apparent diffusion coefficient(ADC)value decreased in different pathological types of lung cancer.Among them,ADC value was higher in patients with adenocarcinoma than in patients with small cell lung cancer and squamous cell carcinoma of different b values(all P<0.05).With the increase of b value,ADC value decreased in patients with adenocarcinoma of different differentiation degree,and ADC value was higher in patients with adenocarcinoma of high differentiation than in patients with adenocarcinoma of low differentiation(all P<0.05).When b value is 0 to 800 s/mm2,the area under receiver operating characteristic(ROC)curve was the largest,and the sensitivity and specificity were the highest.Conclusion DWI can provide information on functional parameters including cell structure and cell membrane integrity for lung cancer,which is helpful for the early detection of lung cancer and the description of tumor characteristics,and has high clinical value for the diagnosis and differential diagnosis of lung cancer.

关 键 词：磁共振弥散加权成像 肺肿瘤 诊断价值 

分 类 号：R734.2[医药卫生—肿瘤]