气相色谱-质谱联用技术分析制痂酊中挥发性成分  

Identification of the volatile components in ZhiJia tincture by GC–MS

作　　者：陆静金 夏泉[1,2] LU jingjin;XIA Quan(Department of Pharmacy,The First Affiliated Hospital of Anhui Medical University,Hefei,Anhui 230022,China;The Grade 3 Pharmaceutical Chemistry Laboratory of State Administration of Tra-ditional Chinese Medicine,Hefei,Anhui 230022,China)

机构地区：[1]安徽医科大学第一附属医院药剂科,安徽合肥230022 [2]国家中医药管理局中药化学三级实验室,安徽合肥230022

出　　处：《安徽医药》2021年第5期868-869,共2页Anhui Medical and Pharmaceutical Journal

摘　　要：目的分析制痂酊中挥发性成分。方法采用气相色谱-质谱联用(GC–MS)技术分析制痂酊中的挥发性成分,通过wiley7n.1标准谱库检索和文献对比鉴定各挥发性成分,采用面积归一化法计算各挥发性成分的相对百分含量。结果制痂酊中鉴定了13个挥发性成分,主要为异龙脑(40.99%)、龙脑(55.18%)、1,3,3-三甲基-二环[2.2.1]庚烷-2-醇(1.01%)、外型-1,7,7-三甲基-二环[2.2.1]庚-2-醇(1.01%)。结论运用GC–MS技术全面地分析了制痂酊中挥发性成分,为制痂酊质量控制提供科学依据。Objective To study the chemical constituent of the volatile components of ZhiJia tincture.Methods The volatile components of ZhiJia tincture were analyzed by gas chromatography mass spectrometry(GC–MS).The volatile components were identified by wiley7 n.1 library and literature comparison,the relative percentage contents of which were calculated by area normalization method.Results A total of 13 volatile components were identified from ZhiJia Tincture,including isoborneol(40.99%),borneol(55.18%),1,3,3-trimethyl-bicyclo[2,2,1]heptan-2-ol(1.01%)and exo-1,7,7-trimethyl-bicyclo[2,2,1]heptan-2-ol(1.01%).Conclusion Volatile components in the ZhiJia tincture are analyed by GC–MS,which provides scientific references for quality control of ZhiJia tincture.

关 键 词：中草药 主成分分析 气相-质谱联用技术 制痂酊 挥发性成分 

分 类 号：R284.1[医药卫生—中药学]