外周血亲环素B、胃泌素释放肽前体、维生素D结合蛋白在胃癌根治术病人中的表达及对术后复发的影响  

Expression of CypB, ProGRP, VDBP in peripheral blood in patients with radical gastric cancer and its effect on postoperative recurrence

作　　者：梁改红[1] 陈艳红[2] LIANG Gaihong;CHEN Yanhong(Department of Surgery,Pingdingshan First People's Hospital,Pingdingshan,Henan 467000,China;Department of Operation,the First Affiliated Hospital of Zhengzhou University,Zhengzhou,Henan 450052,China)

机构地区：[1]平顶山市第一人民医院手术部,河南平顶山467000 [2]郑州大学第一附属医院手术部,河南郑州450052

出　　处：《安徽医药》2021年第5期970-974,共5页Anhui Medical and Pharmaceutical Journal

摘　　要：目的探究外周血亲环素B(CypB)、胃泌素释放肽前体(ProGRP)、维生素D结合蛋白(VDBP)在胃癌根治术病人中的表达及对术后复发的影响。方法选取2014年1月至2016年10月平顶山市第一人民医院收治的94例胃癌病人作为研究对象,均行胃癌根治术,并随访2年或至复发止。根据术后2年内是否复发分为复发组(40例)、未复发组(54例)。比较两组临床病理特征、术前、术后1个月、术后2年或复发时血清CypB、ProGRP、VDBP水平,分析胃癌根治术后复发的影响因素及血清各指标对术后复发的诊断价值。并采用Kaplan-Meier曲线进行生存分析。结果两组淋巴结转移、TNM分期、分化程度、浸润深度差异有统计学意义(P<0.05);术后1个月两组血清CypB、ProGRP水平低于术前,VDBP水平高于术前(P<0.05),组间对比差异无统计学意义(P>0.05);复发组复发时血清CypB、ProGRP高于未复发组,VDBP水平低于未复发组(P<0.05);TNM分期、浸润深度、血清CypB、ProGRP、VDBP是胃癌根治术后复发的重要影响因素(P<0.05);各血清指标中,CypB诊断胃癌根治术后复发的AUC最大,为0.772。CypB、ProGRP、VDBP等三指标联合应用的诊断价值更高,其灵敏度和特异度分别为92.50%(37/40)、90.74%(49/54)。血清CypB、ProGRP、VDBP低表达组、高表达组生存曲线对比,差异有统计学意义(P<0.05)。结论胃癌根治术后复发受多种因素影响,其中血清CypB、ProGRP、VDBP的异常表达与术后复发密切相关,在复发诊断方面具有较高应用价值,且能作为评估复发病人生存率的重要指标。Objective To explore the expressions of peripheral blood cyclophilin B(CypB),gastrin-releasing peptide(ProGRP),and vitamin D-binding protein(VDBP)in patients with radical gastrectomy and their effects on postoperative recurrence.Methods A total of 94 patients with gastric cancer treated in Pingdingshan First People’s Hospital from January 2014 to October 2016 were selected as the research objects.All patients underwent radical gastric cancer surgery.They were divided into relapse group(40 cases)and non-recurrence group(54 cases).The clinical and pathological characteristics,serum levels of CypB,ProGRP,and VDBP before and after recurrence were compared between the two groups,and the influential factors of recurrence after gastric cancer radical resection and the diagnostic value of serum indexes for recurrence were analyzed.Follow-up for 2 years,Kaplan-Meier curve was used for survival analysis.Results There were significant differences in lymph node metastasis,TNM stage,differentiation degree,and depth of infiltration between the two groups(P<0.05).CypB and ProGRP levels in the two groups were lower than before surgery,and VDBP levels were higher than before surgery(P<0.05).0.05),there was no statistically significant difference between the groups(P>0.05);CypB and ProGRP in the relapsed group were higher than those in the non-relapsed group,and VDBP levels were lower than those in the non-relapsed group(P<0.05);lymph node metastasis,TNM staging,The degree of differentiation,depth of invasion,serum CypB,ProGRP,and VDBP are important influencing factors for recurrence of gastric cancer after radical resection(P<0.05).Among all serum indicators,CypB has the largest AUC of 0.762 for recurrence of gastric cancer after radical resection,the best diagnosis.The sensitivity was 62.50%and the specificity was 83.33%.The survival curves of CypB,ProGRP,VDBP low-risk group and high-risk group were compared,and the difference was statistically significant(P<0.05).Conclusion The recurrence of gastric cancer after radical resec

关 键 词：胃肿瘤 胃切除术 亲环素B 胃泌素释放肽前体 维生素D结合蛋白 复发 

分 类 号：R735.2[医药卫生—肿瘤]