β连环素和Ki-67表达在唾液腺腺样囊性癌和基底细胞腺癌鉴别诊断中的作用  

The role of β-catenin and Ki-67 expressions in differential diagnosis of salivary adenoid cystic carcinoma and basal cell adenocarcinoma

作　　者：夏荣辉[1] 王丽珍[1] 顾挺[1] 张莺[1] 钱佳骏 薛俊青 田臻[1] 李江[1] XIA Ronghui;WANG Lizhen;GU Ting(Department of Oral Pathology,Shanghai Ninth People’s Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200011,CHINA)

机构地区：[1]上海交通大学医学院附属第九人民医院口腔病理科(国家口腔疾病临床医学研究中心),200011

出　　处：《江苏医药》2021年第3期230-233,F0003,共5页Jiangsu Medical Journal

基　　金：国家自然科学基金(81702694);上海交通大学医学院附属第九人民医院精才计划(JC201901)。

摘　　要：目的探讨β连环素(β-catenin)和Ki-67表达在唾液腺腺样囊性癌(ACC)和基底细胞腺癌(BCAC)鉴别诊断中的作用。方法回顾性分析56例唾液腺ACC患者(A组)和32例BCAC患者(B组)的临床资料,比较两组组织病理学特征。通过免疫组化染色检测并比较两组β-catenin和Ki-67蛋白的表达。结果 A组神经侵犯比例和肿瘤位于小唾液腺比例高于B组(P<0.01),而两组肿瘤最大径和血管侵犯比例差异无统计学意义(P>0.05)。免疫组化染色结果显示,两组β-catenin染色部位差异明显,A组患者β-catenin均表达于肿瘤细胞膜和细胞质,而B组患者中29例(90.6%)可见β-catenin表达于肿瘤细胞核(P<0.01)。A组Ki-67指数高于B组[(15.5±1.6)%vs.(4.2±0.7)%](P<0.01)。结论β-catenin在细胞内表达定位和Ki-67指数可以作为辅助鉴别诊断唾液腺ACC和BCAC的指标。Objective To investigate the role of β-catenin and Ki-67 expressions in the differential diagnosis of salivary adenoid cystic carcinoma(ACC) and basal cell adenocarcinoma(BCAC).Methods The clinical data of 56 patients with salivary ACC(group A) and 32 patients with BCAC(group B) were retrospectively analyzed.The histopathological characteristics of two groups were compared.The protein expressions of β-catenin and Ki-67 in two groups were detected by immunohistochemical staining.Results The proportions of the patients with nerve invasion and tumors located in the salivary glands were higher in group A than those in group B(P<0.01),but there were no significant differences between the two groups in the largest diameter of tumors and the proportion of vascular invasion(P>0.05).Immunohistochemical staining results showed that the difference of β-catenin staining position location between the two groups was statistically significant, β-catenin was expressed in the tumor cell membrane and cytoplasm in group A,while which was expressed in tumor cell nuclei in 29 cases(90.6%) of the patients in group B(P<0.01).The Ki-67 index of group A was higher than that of group B [(15.5±1.6)% vs.(4.2±0.7)%](P<0.01).Conclusion The location of β-catenin expression in the cells and Ki-67 index can be used as the auxiliary indicators to distinguish ACC and BCAC of the salivary glands.

关 键 词：唾液腺 腺样囊性癌 基底细胞腺癌 Β连环素 Ki-67 

分 类 号：R739[医药卫生—肿瘤]