康柏西普辅助小梁切除联合手术治疗前房角关闭期新生血管性青光眼  

Conbercept assisted trabeculectomy combined with panretinal photocoagulation in the treatment of nevoascular glaucoma with anterior chamber angle closure

作　　者：谷军峰 剡晓川[1] 魏亚明[1] Gu Junfeng;Yan Xiaochuan;Wei Yaming(Department of Ophthalmology,The 944th Hospital of Chinese People’s Liberation Army,Jiuquan,Gansu 735000,China)

机构地区：[1]中国人民解放军第944医院眼科,酒泉735000

出　　处：《中华眼外伤职业眼病杂志》2021年第4期254-258,共5页Chinese Journal of Ocular Trauma and Occupational Eye Disease

摘　　要：目的:分析康柏西普辅助小梁切除联合广泛视网膜光凝治疗前房角关闭期新生血管性青光眼的效果。方法:回顾性分析解放军第944医院2017年3月至2019年11月前房角关闭期新生血管性青光眼82例(82只眼)的临床资料。患者分为两组:观察组,43例(43只眼),行康柏西普玻璃体内注射辅助小梁切除联合广泛视网膜光凝术;对照组,39例(39只眼),行单纯小梁切除术联合广泛视网膜光凝术。观察两组手术后视力、眼压及手术并发症。术后随访6个月。结果:观察组视力提高率为13.95%(6/43),对照组为10.26%(4/39),差异有统计学意义(χ^(2)=6.125,P=0.030)。两组患者术后眼压均下降,观察组眼压低于对照组(t=11.910,P<0.001),观察组总有效率高于对照组(χ^(2)=8.510,P=0.003);观察组术后并发前房积血发生率低于对照组(χ^(2)=6.125,P=0.001),两组均无眼内大出血、感染性眼内炎、巩膜坏死、视网膜脱离或睫状环阻塞性青光眼等严重并发症发生。结论:玻璃体内注射康柏西普辅助小梁切除术联合广泛视网膜光凝术治疗前房角关闭期新生血管性青光眼,效果确切,安全性好。Objective To analyze the efficacy of conbercept assisted trabeculectomy combined with panretinal photocoagulation in the treatment of neovascular glaucoma with closed anterior chamber angle.Methods This was a retrospective analysis.The clinical data of 82 eyes of 82 cases of neovascular glaucoma with anterior chamber angle closure from Mar.2017 to Nov.2019 in the 944 Hospital of the People’s Liberation Army were retrospectively analyzed.The patients were divided into two groups.Forty-three eyes of 43 cases in the observation group received conbercept intravitreal injection assisted trabeculectomy combined with panretinal photocoagulation.Thirty-nine eyes of 39 cases in the control group received only trabeculectomy combined with panretinal photocoagulation.The visual acuity,intraocular pressure and surgical complications of the two groups after the operation were observed.The follow-up time was 6 months after surgery.Results The rate of visual acuity improvement in the observation group was 13.95%(6/43),which was higher than the 10.26%(4/39)in the control group,the difference was statistically significant(χ^(2)=6.125,P=0.030).The intraocular pressure of the two groups of patients decreased after operation.The intraocular pressure of the observation group was lower than that of the control group(t=11.910,P<0.001).The total effective rate of the observation group was higher than that of the control group(χ^(2)=8.510,P=0.003).The incidence of hyphema of observation group was lower than that of the control group(χ^(2)=6.125,P=0.001).There was no serious complication such as intraocular hemorrhage,infectious endophthalmitis,scleral necrosis,retinal detachment or ciliary block glaucoma in both groups.Conclusion Intravitreal injection of conbercept assisted trabeculectomy combined with panretinal photocoagulation in the treatment of neovascular glaucoma with anterior chamber angle closure was effective and safe.

关 键 词：玻璃体内注射 血管内皮生长因子 青光眼 新生血管性 小梁切除术 

分 类 号：R779.6[医药卫生—眼科]