非小细胞肺癌患者血脂联合检测分析  

Analysis of serum lipid level in patients with non-small cell lung cancer

作　　者：袁绪龙 赵嫚 纪波 穆玉恕 YUAN Xu-long;ZHAO Man;JI Bo;MU Yu-shu(The Second Affiliated Hospital of Shandong First Medical University,Taian 271000,China)

机构地区：[1]山东第一医科大学第二附属医院,山东泰安271000

出　　处：《泰山医学院学报》2021年第4期267-269,共3页Journal of Taishan Medical College

基　　金：北京市科委尿干化学检验与疾病符合程度分析(2018-KF10);尿液细胞分子诊断北京市重点实验室建设经费(2019-JS02)。

摘　　要：目的分析非小细胞肺癌患者与正常人血清中总胆固醇(CHOL)、甘油三酯(TG)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)、载脂蛋白A(ApoA)、载脂蛋白B(ApoB)、游离脂肪酸(FFA)的水平,探讨非小细胞肺癌和血脂相关性。方法对267例非小细胞肺癌患者、260例正常人采用BECKMAN COULTER AU5800全自动生化分析仪测定其外周血脂水平,采用SPSS 18.0软件对各组数据进行统计学分析。结果非小细胞肺癌患者组和观察组血脂分析:CHOL、TG、HDL、LDL、ApoA在2组间差异无统计学意义(P>0.05);非小细胞肺癌患者组的ApoB和FFA水平高于对照组,差异有统计学意义(P<0.05)。结论血脂联合检测中ApoB、FFA在非小细胞肺癌患者组中显著升高,提示ApoB、FFA可能在非小细胞肺癌病变的发生发展过程中起到了一定的作用。Objective:To analyze the cholesterol(CHOL),triglycerides(TG),high density lipoprotein(HDL),low density lipoprotein(LDL),apolipoprotein A(ApoA),apolipoprotein B(ApoB),and free fatty acid(FFA)in patients of non-small cell lung cancer and normal people.The relationship between non-small cell lung cancer and serum lipids was explored as well.Methods:BECKMAN COULTER AU5800 automatic biochemical analyzer was used to determine the serum lipid levels of 267 patients with non-small cell lung cancer and 260 normal people.SPSS 18.0 was used to statistically analyze the data of two groups.Results:Analysis of the non-small cell lung cancer patient group and the control group showed that CHOL,TG,HDL,LDL,ApoA were not statistically different between the two groups(P>0.05).The levels of ApoB and FFA in the non-small cell lung cancer patient group were higher than those in the control group.The difference was statistically significant(P<0.05).Conclusion:The detection of serum lipids,ApoB and FFA are significantly increased in the non-small cell lung cancer patient group,suggesting that Apo B and FFA play a certain role in the development of non-small cell lung cancer.

关 键 词：非小细胞肺癌 血脂分析 载脂蛋白B 游离脂肪酸 

分 类 号：R734.2[医药卫生—肿瘤]