代谢综合征相关指标对结直肠癌患者根治术预后的影响  

The influence of metabolic syndrome related indicators on the prognosis of colorectal cancer patients undergoing radical resection

作　　者：朱小丽[1] 胡金喜[2] ZHU Xiaoli;HU Jinxi(Department of Clinical Laboratory,Taizhou Hospital of Zhejiang Province,Taizhou317000,China;Department of Tumor Surgery,Taizhou Hospital of Zhejiang Province,Taizhou317000,China)

机构地区：[1]浙江省台州医院检验科,浙江台州317000 [2]浙江省台州医院肿瘤外科,浙江台州317000

出　　处：《中国现代医生》2021年第9期134-138,共5页China Modern Doctor

基　　金：浙江省医药卫生科技计划项目(2018KY889);浙江省台州市科技计划项目(1702KY06,1702KY25)。

摘　　要：目的分析代谢综合征(MS)相关指标与结直肠癌患者行根治术术后预后的影响。方法选取2010年12月至2013年11月在本院行结直肠癌根治术治疗的患者234例,收集患者的临床信息及实验室检测指标,跟踪随访患者术后情况,用生存曲线分析糖尿病、脂代谢紊乱、高血压及肥胖对患者术后预后的影响。结果234例结肠癌患者中,MS患者占8.11%,糖尿病、脂代谢紊乱、高血压及肥胖患者分别占23.93%、26.06%、28.20%及15.38%。高血压患者发生术后并发症的比例显著高于非高血压患者,差异有统计学意义(P=0.013)。经年龄校准,肥胖是结直肠癌死亡的高风险因素[HR:1.11(1.01~1.22),P=0.041]。MS对结直肠癌患者术后总生存期(OS)并无明显影响(P=0.722);高血压患者OS短于非高血压患者,差异有统计学意义(P<0.01)。结论高血压是结直肠癌根治术患者术后并发症发生及影响OS的不利因素,肥胖是结直肠癌死亡的高风险因素。Objective To analyze the influence of metabolic syndrome(MS)related indicators on the prognosis of patients with colorectal cancer after radical resection.Methods Clinical information and laboratory indexes of 234 patients undergoing radical resection of colorectal cancer in our Hospital from December 2010 to November 2013 were collected.The postoperative status of the patients was followed up.The survival curve was used to analyze the influence of diabetes,lipid metabolism disorder,hypertension and obesity on postoperative prognosis of the patients.Results Among the 234 colon cancer patients,8.11%were MS patients,23.93%were diabetes,26.06%were lipid metabolism disorder,28.20%were hypertension and 15.38%were obesity.The rate of postoperative complications in hypertensive patients was statistically significantly higher than that in non-hypertensive patients(P=0.013).By age adjustment,obesity was a risk factor for colorectal cancer death(HR:1.11[1.01~1.22],P=0.041).MS had no significant effect on postoperative overall survival(OS)of colorectal cancer patients(P=0.722),but the OS of hypertensive patients was shorter than that of non-hypertensive patients,and the difference was statistically significant(P<0.01).Conclusion Hypertension is an adverse factor affecting postoperative complications and OS in patients undergoing radical resection for colorectal cancer,and obesity is a high risk factor for colorectal cancer death.

关 键 词：代谢综合征 结直肠癌 根治术 预后 

分 类 号：R735.3[医药卫生—肿瘤]