224例中高危险度胃肠间质瘤手术根治程度结合靶向治疗的生存预后分析  

Analysis of survival prognosis of degree of surgical treatment with targeted therapy for 224 cases of intermediate-and high-risk gastrointestinal stromal tumors patients

作　　者：崔仪 韩振国[2] CUI Yi;HAN Zhen-guo(Graduate School of Shanxi Medical University, Taiyuan 030001;Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Taiyuan 030010, China)

机构地区：[1]山西医科大学研究生学院,山西太原030001 [2]山西医学科学院山西白求恩医院,山西太原030010

出　　处：《基础医学与临床》2021年第5期667-673,共7页Basic and Clinical Medicine

基　　金：山西省重点研发计划(201603D321052)。

摘　　要：目的探讨中高危险度胃肠间质瘤(GIST)患者手术根治程度及靶向药物治疗与生存预后的相关性,进而总结临床诊疗经验。方法回顾性分析2012年9月至2019年12月山西白求恩医院手术和病理确诊的中高危险度GIST患者完整的临床病理及随访资料,归纳总结影响其预后的相关因素。结果患者性别、年龄、肿瘤部位、是否破裂、手术根治程度、靶向治疗与3年、5年总体生存期(OS)均有差异(P<0.05)。GIST患者的原发肿瘤位置、肿瘤是否破裂、手术根治程度、靶向治疗是影响其3年及5年OS的独立预后因素。不同手术根治程度、不同危险度分级及是否应用靶向药物治疗与患者的预后有差异(P<0.05)。结论完整手术切除(R0)结合靶向治疗是改善中高危险度GIST患者预后的主要治疗手段,但中危险度GIST患者术后接受靶向药物治疗对其总生存期改善程度的差异无统计学意义。Objective To explore the degree of radical surgery for patients with intermediate-and high-risk gastrointestinal stromal tumors(GIST)and to find the correlation between targeted drug therapy and survival prognosis,and then to summarize the clinical diagnosis and treatment experience.Methods A retrospective reciew of the complete pathological and follow-up data of intermediate and high risk GIST patients diagnosed by surgery and pathology in Shanxi Bethune Hospital from September 2012 to December 2019 was made,and the relevant factors that affect their prognosis.Results The patient's gender,age,tumor location,whether it was ruptured,the degree of radical surgery was summarized,targeted therapy,and the overall survival(OS)of 3 and 5 years were different(P<0.05).The location of the primary tumor in GIST patients,whether the tumor was ruptured,the degree of radical surgery,and targeted therapy were independent prognostic factors that affected their 3-year and 5-year OS.There were differences in theprognosis of patients with different degrees of radical surgery,different risk grades,and whether to use targeted drug therapy(P<0.05).Conclusions Complete surgical resection(R0)combined with targeted therapy is the main treatment to improve the prognosis of patients with intermediate-and high-risk GIST,but patients with intermediate-risk GIST who received targeted drug therapy after surgery are failed to significantly improve their overall survival.

关 键 词：中高危险度 胃肠间质瘤 手术根治程度 生存预后因素 

分 类 号：R735[医药卫生—肿瘤]